2018
DOI: 10.1111/1759-7714.12892
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Spontaneous regression of lung squamous cell carcinoma with synchronous mediastinal progression: A case report

Abstract: Spontaneous regression (SR) of cancer implies the partial or complete disappearance of malignant disease without or with adequate medical treatment. Typically, SR of cancer is a sporadic event, especially in non‐small cell lung cancer (NSCLC). Although the underlying mechanism of SR remains unknown, stimulation of an immunological response has been proposed. Herein, we report the case of a 56‐year‐old woman exhibiting SR of NSCLC with a mediastinal disease. Despite regression of the primary site after a lung b… Show more

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Cited by 7 publications
(11 citation statements)
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“…Spontaneous regression of SCLC has previously been reported. In 2018, Matsui et al [ 11 ] described a case of partial regression of SCLC with mediastinal lymph node metastasis. In this case, the primary tumor regressed following biopsy, while metastasis of mediastinal lymph nodes progressed.…”
Section: Discussionmentioning
confidence: 99%
“…Spontaneous regression of SCLC has previously been reported. In 2018, Matsui et al [ 11 ] described a case of partial regression of SCLC with mediastinal lymph node metastasis. In this case, the primary tumor regressed following biopsy, while metastasis of mediastinal lymph nodes progressed.…”
Section: Discussionmentioning
confidence: 99%
“…16 Similarly, biopsies have been shown to induce local, and to some degree, systemic inflammation resulting in tumor resolution. 17 Further studies are required, but prior reports suggest that pyrogenic reaction is correlated with an induced immune response which has potential in eliminating tumor burden and leading to tumor resolution. 16…”
Section: Discussionmentioning
confidence: 99%
“…Infections elicit a strong immunological response and fever, and the presence of a fever has been recorded in up to 80% of patients with spontaneous tumor regression cases—many of which presented with severe systemic illnesses such as malaria, measles, or tuberculosis 16 . Similarly, biopsies have been shown to induce local, and to some degree, systemic inflammation resulting in tumor resolution 17 . Further studies are required, but prior reports suggest that pyrogenic reaction is correlated with an induced immune response which has potential in eliminating tumor burden and leading to tumor resolution 16 …”
Section: Discussionmentioning
confidence: 99%
“…1 Although SR of cancer is extremely rare and the incidence of SR is approximately one in every 60,000 to 100,000 cancer patients, certain clinicians can have a chance to experience this intriguing phenomenon. 2 The mechanism of SR remains to be elucidated, but the inflammation and immunologic reaction have been considered as one of the means of SR. 3,4 Here, we present a case of a patient who had suppurative inflammation and superficial squamous cell carcinoma, which spontaneously regressed in the left lingular segment.…”
Section: Introductionmentioning
confidence: 99%