Spontaneous regression of Merkel cell carcinoma of the skin

Yanguas, I.; Goday, J.J.; González-Güemes, Magdalena; Oleaga, J. M.; Lozano, M; Soloeta, R.

doi:10.1046/j.1365-2133.1997.18251927.x

Cited by 55 publications

(36 citation statements)

References 8 publications

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“…25 In the present review, 3.3% of cases presented with metastasis from an unknown primary, suggesting regression of the primary MCC. In addition, immune compromise appears to play a role in the epidemiology of this cancer.…”

Section: Discussionmentioning

confidence: 50%

Multimodality Treatment of Merkel Cell Carcinoma: Case Series and Literature Review of 1024 Cases

et al. 2001

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Section: Discussionmentioning

confidence: 50%

Multimodality Treatment of Merkel Cell Carcinoma: Case Series and Literature Review of 1024 Cases

et al. 2001

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“…The incidence varies from 0% to 18%, 3,4,8,15 and can be attributed to spontaneous regression of the primary 18 or metastatic neuroendocrine carcinoma from a noncutaneous site. The incidence in this series was proportionally higher (25%) and may be as a result of several factors.…”

Section: Discussionmentioning

confidence: 99%

High-Risk Merkel Cell Carcinoma of the Skin Treated With Synchronous Carboplatin/Etoposide and Radiation: A Trans-Tasman Radiation Oncology Group Study—TROG 96:07

Poulsen

Rischin

Walpole

et al. 2003

JCO

201

115

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Purpose: The effectiveness of synchronous carboplatin, etoposide, and radiation therapy was prospectively assessed in a group of patients with high-risk Merkel cell carcinoma (MCC) of the skin.Patients and Methods: Patients were eligible if they had disease localized to the primary site and nodes, and were required to have at least one of the following high risk features: recurrence after initial therapy, involved nodes, primary tumor size greater than 1 cm, gross residual disease after surgery, or occult primary with nodes. Radiation was delivered to the primary site and nodes to a dose of 50 Gy in 25 fractions over 5 weeks and synchronous carboplatin (area under the curve, 4.5) and intravenous etoposide 80 mg/m 2 days 1 to 3 was given in weeks 1, 4, 7, and 10. The median age of the group was 67 (range, 43-86) years, and there were 39 males and 14 females. Involved nodes (stage II) were present in 33 cases (62%). The sites involved were head and neck (22 patients), occult primary (13 patients), upper limb (eight patients), lower limb (eight patients), and trunk (two patients).Results: Fifty-three patients were entered between 1996 and 2001. The median potential follow-up was 48 months. There were no treatment related deaths. The 3-year overall survival, locoregional control, and distant control were 76%, 75%, and 76%, respectively. Tumor site and the presence of nodes were factors that were predictive for local control and survival. Multivariate analysis indicated that the major factor influencing survival was the presence of nodes; however, this was not a significant factor in locoregional control.Conclusion: High levels of locoregional control and survival have been achieved with the addition of chemotherapy to radiation treatment for high-risk MCC of the skin. The role of chemoradiotherapy for high-risk MCC warrants further investigation.

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“…However, it is well recognized that the spontaneous regression of cutaneous primaries does occur. [19][20][21][22] There is currently no literature on the prognostic implications of occult primary disease despite this representing a significant minority of patients. The aim of this study was to analyze the outcome of patients with stage IIIB (nodal) disease with a focus on the prognostic implications of having occult primary disease with respect to the consensus staging system.…”

mentioning

confidence: 99%

Merkel cell carcinoma: The prognostic implications of an occult primary in stage IIIB (nodal) disease

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Veness

Zarate

et al. 2012

Journal of the American Academy of Dermatology

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Spontaneous regression of Merkel cell carcinoma of the skin

Cited by 55 publications

References 8 publications

Multimodality Treatment of Merkel Cell Carcinoma: Case Series and Literature Review of 1024 Cases

Multimodality Treatment of Merkel Cell Carcinoma: Case Series and Literature Review of 1024 Cases

High-Risk Merkel Cell Carcinoma of the Skin Treated With Synchronous Carboplatin/Etoposide and Radiation: A Trans-Tasman Radiation Oncology Group Study—TROG 96:07

Merkel cell carcinoma: The prognostic implications of an occult primary in stage IIIB (nodal) disease

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