1992
DOI: 10.1016/s0022-5347(17)36537-0
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Spontaneous Regression of Metastases in a Case of Bilateral Renal Cell Carcinoma

Abstract: A patient is described who had undergone bilateral nephrectomy for renal cell carcinoma and who had been maintained on hemodialysis for the last 2 years. A total of 3 months after acceptance into the program he was found histologically to have metastatic pleural lesions, which had regressed spontaneously 1 1/2 years ago. Repeat clinical and radiological assessment has shown no tumor recurrence.

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Cited by 13 publications
(4 citation statements)
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“…Although the causal role is not clear, transient pleural effusion and the withdrawal of INF‐α preceded the unexplained regression. Interestingly, Kallmeyer and Dittrich also reported a case of an RCC patient whose pleural metastasis regressed after the development of pleural effusion 3 …”
Section: Discussionmentioning
confidence: 99%
“…Although the causal role is not clear, transient pleural effusion and the withdrawal of INF‐α preceded the unexplained regression. Interestingly, Kallmeyer and Dittrich also reported a case of an RCC patient whose pleural metastasis regressed after the development of pleural effusion 3 …”
Section: Discussionmentioning
confidence: 99%
“…The high incidence of patients on placebo who achieved either a CR or PR raises specific questions about the evaluation of treatment response in patients with metastatic RCC. Spontaneous remission of RCC, as defined previously [4], has been reported in open‐label, non‐comparative clinical trials to have an incidence of 0–7% [13,22–35]. Typically, spontaneous remission occurs in men aged 30–76 years and the regression of lung metastases is most commonly reported [22–24].…”
Section: Discussionmentioning
confidence: 99%
“…Typically, spontaneous remission occurs in men aged 30–76 years and the regression of lung metastases is most commonly reported [22–24]. The incidence of spontaneous regression is greater after nephrectomy, but there has been unexpected complete regression after hormonal therapy or radiation therapy [26,27]. The reported duration of remission is variable, ranging from 3 months to 20 years.…”
Section: Discussionmentioning
confidence: 99%
“…Spontaneous regression and response to immunotherapy are two unique characteristics of RCC [9, 10, 11, 12]which suggest that immune surveillance may be involved in the regression of this tumor. We used molecular techniques to investigate the relationships between HLA-DR antigens/alleles and RCC in Japanese patients.…”
Section: Introductionmentioning
confidence: 99%