Spontaneous regression of multiple intracranial capillary hemangiomas in a newborn—long-term follow-up and literature review

Background: OPG accounts for 3–5% of childhood central nervous system (CNS) tumors and about 2% of pediatric glial lesions. Methods: Article selection was performed by searching PubMed, Web of Science, and Cochrane databases. Results: The pooled mortality rate was 0.12 (95%CI 0.09–0.14). Due to the unrepresentative data, improved and not changed outcomes were classified as favorable outcomes and worsened as unfavorable. Meta-analyses were performed to determine the rate of clinical and radiological favorable outcomes. In terms of visual assessment, the pooled rate of a favorable outcome in chemotherapy, radiotherapy, and surgery was 0.74, 0.81, and 0.65, respectively, and the overall pooled rate of the favorable outcome was 0.75 (95%CI 0.70–0.80). In terms of radiological assessment, the rate of a favorable outcome following chemotherapy, radiotherapy, and surgery was 0.71, 0.74, and 0.67, respectively, and the overall pooled rate of the favorable outcome is 0.71 (95%CI 0.65–0.77). The subgroup analysis revealed no significant difference in the rate of clinical and radiological favorable outcomes between the different treatment modalities (p > 0.05). Conclusion: Our analyses showed that each therapeutic modality represents viable treatment options to achieve remission for these patients.

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Methods of Treatment of Hemangiomas

Nebotova,

Gasanov,

Makhsubova

et al. 2023

Clin Cancer Investig J

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Spontaneous regression of multiple intracranial capillary hemangiomas in a newborn—long-term follow-up and literature review

Cited by 3 publications

References 34 publications

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Adult transverse sinus capillary hemangioma: case report and review of the literature

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Methods of Treatment of Hemangiomas

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