Spontaneous regression of oral mucosal malignant melanoma

Oliveira, Andressa Almeida de; I-Ching, Lee; Teixeira, Gilberto Vaz

doi:10.4322/ahns.2020.0017

Cited by 1 publication

(2 citation statements)

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“…Spontaneous regression in metastatic melanomas is rare and the pathophysiology of regression of mucosal melanoma is not completely understood. The majority of spontaneous regression studies in mucosal melanoma refer to the cutaneous type and suggest that it may be caused by an interaction between melanoma cells and the host immune system, resulting in killing of melanoma cells, proliferating lymphocytes, telangiectasia, and replacement of tumor tissue by fibrosis (2,5,9,10). Various clinical signs of spontaneous regression have been described such as hypopigmentation, telangiectasia, size reduction, and scarring (2,5).…”

Section: Figmentioning

confidence: 99%

“…Few cases of primary middle ear mucosal melanomas (n ¼ 12) have been reported in the literature (9,10,14). Oliveira et al (9) describes a case of spontaneous regression of an oral mucosal melanoma in a patient who refused treatment with no signs of tumor recurrence 6 years after treatment. Patients from the other reports underwent multimodality treatment such as surgery followed by radiotherapy and/or systemic therapy.…”

Section: Figmentioning

confidence: 99%

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Spontaneous Regression of a Middle Ear Melanoma

Krebbers

Kunst

Baijens

et al. 2021

Otology &Amp; Neurotology

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Objective: To describe a case of complete spontaneous regression of a middle ear melanoma. Patient: We present a case of a 68-year-old man with complaints of unilateral hearing loss and an ipsilateral facial nerve paresis. Radiological and histopathological examination revealed a cT4bN0M0 mucosal melanoma of the middle ear. Interventions: The patient underwent a subtotal petrosectomy and postoperative radiotherapy. Main Outcome Measure: Computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography/computed tomography with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG-PET-CT), and histopathological examination. Results: After subtotal petrosectomy, histopathological examination of the resection specimen showed only fibrosis and a histiocytic and clonal T-cell infiltration, but no residual melanoma at the primary tumor site, consistent with spontaneous tumor regression. Follow-up MRI scanning 6 and 12 months after radiotherapy showed no signs of tumor recurrence. Conclusions: This case describes the concept of spontaneous regression of a mucosal melanoma of the middle ear. Spontaneous tumor regression at this location has not been described before.

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