Spontaneous Regression of Plane Warts After Inflammation

Specific Cell-Mediated Immunity in Patients with Epidermodysplasia verruciformis and Plane Warts

“…The resolution process of flat warts appears to be an im munologic reaction. Abundant lymphocytic and macrophage infiltrates penetrate into the epidermis and destroy epidermal rete ridges [28,29], Also the clinical pattern, i.e. an inflammatory reaction simultaneously occurring in all lesions, associated with itch ing, swelling and erythema of the warts about to regress, is highly characteristic [28].…”

“…The importance of cell-mediated immune re sponse in human papilloma virus (HPV) in fections has been reported repeatedly by var ious investigators [2, 3, 11, 13, 15-18, 30, 31 ], but the presented data were often con troversial. Clinical observations suggest a role for nonspecific cell-mediated immunity (CM I) in wart regression [28], The frequency of warts in patients with immune deficiency syndromes and those undergoing immuno suppressive therapy is significantly higher [11,17,27] and the agents known to stimu late CM I have been reported to precipitate the resolution of warts [26,30,31]. Recently, it has been shown that nonspecific CM1 is significantly decreased in some types of HPV infections, especially in those induced by epidermodysplasia verruciformis (EV)-specific HPVs [5 ,8 ,9 ,1 4 .…”

Immunocompetent Cells in Uterine Cervical Lesions of Human Papillomavirus Origin

“…In the flat warts of the skin (HPV 3) studied histologically, the state of regression is always associated with a pronounced mononuclear cell infiltra tion [1,32,33]. On the other hand, cutaneous common warts (HPV 2) showing clinical features of involution did not contain any mononuclear cell infiltration at all or only in 8% of cases [2,13].…”

“…Yet such lesions are found with increasing frequency in young, sexually active female, not infrequently associated with epithelial dysplasias and even with invasive carcinomas [28,29], Thus, we are here dealing with an important group of patients, the factors influencing the future outcome of their HPV lesions being com pletely unknown as yet [28,29], It seems feasible to suggest, however, that factors of both the tumor and of host origin are involved in this process, as they do in tumors elsewhere [7,8,31,35], In the present work, an entirely new approach was made by subjecting the HPV lesions of the cervix for analysis of the constituents of their inflammatory cell infiltrates. It is this infiltrate to which regression of cutaneous HPV lesions is attributed [1,13,32,33]. The immunocompetent cells include three main groups; B, T and MPS cells, each being divided into subpopulations with distinct functions in the regulation of an appropriate immune reaction against a diversity of antigens, tumor antigens included [7,8,31,35].…”

“…It is becoming evident, however, that the local immune reactions mediated by B and T lymphocytes and macrophages (MPS cells) in the target tissue do play an important role in tumor rejection [7,8,31,35]. This was also suggested by the observations on inflammatory cell infiltrates associated with regression of cutaneous warts [1,2,27,32,33], The cell types in these infiltrates, whether B, T or MPS cells, were not analyzed, however. The present study seems to be the first, in which the different immunocompetent cells are enumerated in lesions of HPV origin associated with CIN in the uterine cervix.…”