Spontaneous regression of primary malignant melanomas with regional metastases

Analysis of T cell receptor variability in tumor-infiltrating lymphocytes from a human regressive melanoma. Evidence for in situ T cell clonal expansion.

“…In Situ T Cell Clonality in Regressive Melanoma 1187 ( 17,(26)(27)(28) were present (see Fig. 1, A The results showed that 84% of the V,316 transcripts analyzed in the tumor corresponded to the same cDNA clone while all were different in autologous PBL.…”

Primary Melanoma of Infra Temporal Fossa: A Case Report

“…Various theories have been postulated to explain MUP such as the spontaneous regression of the primary site due to involvement of immunological mechanisms. The first one proposed by Smith and Stehlinin in 1965 support the disappearance of a primary lesion as a result of spontaneous regression after metastasis has occurred [9]. Partial or complete spontaneous resolution of melanoma cells from the primary site is fairly common and it has been actually described in various studies [10].…”

Estudo da espessura da regressão como fator prognóstico nos melanomas cutâneos finos

“…A regressão espontânea representa a resposta imunológica do hospedeiro contra a neoplasia (8,29,31,34,36) . A partir desse conceito, seria coerente esperar melhor evolução nos pacientes que apresentam tal reação.…”

“…A regressão, descrita em melanomas pela primeira vez na literatura por Smith e Stehlin (34) em 1965, é a redução do volume tumoral pela resposta imunológica do hospedeiro e tem sido relatada em diversas entidades como nevo melanocítico (nevo halo) e carcinoma basocelular (11,25) , sendo freqüente nos melanomas (4,8,25) .…”

“…• infiltrado de células mononucleares relacionado diretamente com as células tumorais, podendo infiltrar a epiderme (6,13,14,18,25,34) ;…”