Spontaneous Regression of Radiologically Diagnosed Epidermoid Cyst Originating from the Cerebellopontine Angle

Kaneko, Tomoki; Fujinaga, Yukihisa; Ichinohe, Fumihito; Ogiwara, Toshihiro; Horiuchi, Tetsuyoshi

doi:10.1016/j.wneu.2020.09.008

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Epidermoid cysts are slow-growing, benign lesions that are usually asymptomatic for many years. Epidermoid cysts are variable and exhibit multiple outcomes as the disease progresses, such as resolution, hemorrhage, and malignant transformation ( 10–12 ); however, when symptoms and signs develop rapidly, enhancement of lesion margins and nodular enhancement suggest the possibility of malignant transformation of epidermoid cysts ( 13 ). Patchy enhancement of adjacent tissues of epidermoid cysts has been reported to indicate chemical meningitis, but malignant transformation should not be ruled out ( 14 ).…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested ( 15 ) that enhancement of epidermoid cyst margins or nodular enhancement is usually a sign of malignant transformation, and patchy enhancement of lesion margins is often thought to be chemical meningitis due to cyst rupture, but atypical for malignant transformation. It has also been suggested ( 10 ) that almost all cases have worsening of signs and different degrees of enhancement of lesions before malignant transformation, so atypical enhancement methods need to be combined with patients’ signs to make the best diagnosis.…”

Section: Discussionmentioning

confidence: 99%

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The imaging dynamic changes in the malignant transformation of an epidermoid cyst: a case report and literature review

Yang,

Hu,

et al. 2024

Front. Neurol.

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Malignant transformation of epidermoid cysts is a rare complication. Most of the previously reported cases have involved postoperative malignant transformations. We present a case of malignant transformation of a nonpostoperative epidermoid tumor into squamous cell carcinoma (SCC) that occurred in a 61-year-old Chinese woman. The patient’s initial cranial MRI scan showed an epidermoid cyst with marginal enhancement in the pre-pontine cistern, and the lesion gradually enlarged after 10 months. A craniotomy was performed using to remove part of the tumor via the right retrosigmoid approach, and postoperative pathology confirmed that the transformation of the epidermoid cyst was malignant. Our case study suggests that the possibility of malignant transformation of epidermoid cyst should not be ignored on the basis of enhanced imaging features, regardless of whether they are nodular, annular, or patchy, as is the case for inflammation. Strict follow-up is required for early detection of malignant transformation to prompt correspondingly early clinical treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%