Spontaneous regression of renal cell carcinoma lung metastases in a patient with psoriasis

Melichar, Bohuslav; Vaněčková, J.; Morávek, P; Urminská, Hana; Podhola, Miroslav

doi:10.1080/02841860902882451

Cited by 20 publications

(16 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has been documented in several types of malignancies, such as malignant melanoma [33], neuroblastoma [34], lung cancer [35], renal cell carcinoma [36], [37], hepatocellular carcinoma [38], [39], colorectal cancer [40], and lymphoma [41], [42]. Based on reports in the literature, this occurs less than once in 60,000 to 100,000 people with cancer, with about 20 such cases reported annually among all other cancers [43].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Biopsy Does Not Commonly Induce Intratumoral CD8 T Cell Infiltration in Merkel Cell Carcinoma

et al. 2012

View full text Add to dashboard Cite

BackgroundMerkel cell carcinoma is a polyomavirus-associated cancer that is strongly linked with T lymphocyte immune suppression in epidemiologic studies. CD8+ T cell infiltration into MCC tumors (intratumoral) has recently been shown to be strongly predictive of improved survival. In contrast, the presence of CD8+ T cells at the border of the tumor (peritumoral) had no independent prognostic value. Spontaneous regression has been reported for MCC approximately one thousand times more often than would be expected given the frequency of this cancer. Many of these events began shortly after biopsy, and in some cases lymphocytic infiltration was described.Methodology/Principal FindingsTo determine whether CD8+ lymphocyte infiltration in MCC tumors is commonly altered by biopsy.33 MCC patients who had microscopic confirmation of MCC on both an initial biopsy and a re-excision specimen were included in this study. Intratumoral and peritumoral CD8 lymphocyte infiltration was quantitated using immunohistochemistry and compared using the paired t-test in biopsy versus re-excision samples. There was a trend toward increased CD8 infiltration after biopsy in a peritumoral (‘stalled’) pattern (p = 0.08), however, biopsy was not associated with a significant increase in CD8 T cells in the clinically more important intratumoral location (p = 0.58).Conclusions/SignificanceThe initial diagnostic biopsy for MCC does not commonly alter intratumoral CD8+ T cell infiltration, suggesting it does not directly induce immunologic recognition of this cancer. Because CD8 infiltration is typically stable after biopsy, this parameter may be useful to assess the efficacy of future immune therapies for this virus-associated, immunogenic, often-lethal cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic Biopsy Does Not Commonly Induce Intratumoral CD8 T Cell Infiltration in Merkel Cell Carcinoma

et al. 2012

View full text Add to dashboard Cite

show abstract

“…The second possible reason is a spontaneously regressed primary cancer. Dr. Melichar reported a case in Poland who simultaneously has psoriasis and metastatic RCC to lung [7] Its lung metastasis spontaneously regressed during the exacerbation of psoriasis, explaining the correlation of increased immunity and the spontaneously regression of the metastatic carcinoma. There were also 5 cases of spontaneously regression of primary RCC from 1971 to 2011 among adults in Poland [7].…”

Section: Discussionmentioning

confidence: 99%

Biopsy-Proven Transitional Cell Carcinoma of a Lung Mass Without an Urothelial Origin - A Rare Case Report

Liao¹,

Huang²

2017

J Clin Case Rep

View full text Add to dashboard Cite

A 77-year-old man with smoking history visited Thoracic Surgery department with a complaint of dry cough and dyspnea for months. Chest CT showed a mass over left upper lobe, mediastinal lymph node enlargement and bilateral lung nodules. CT-guide biopsy of the left upper lung mass revealed transitional cell carcinoma. Nevertheless, no primary origin was discovered after a thorough evaluation of genitourinary tract, including abdominal CT, FDG-PET, cystoscopy and retrograde pyelography. We will discuss the possible reasons for the unknown primary origin of transitional cell carcinoma in a lung mass.

show abstract

“…In several case reports, this regression occurred simultaneously with an autoimmune flair (e.g. psoriasis) [17,18]. Subsequent studies have suggested that cytoreductive surgery of the primary tumor prior to cytokine therapy is associated with superior outcomes.…”

Section: Introductionmentioning

confidence: 99%

PD-1/PD-L1 blockade in renal cell cancer

Beckermann

Johnson

Sosman

2016

Expert Review of Clinical Immunology

View full text Add to dashboard Cite

Introduction Immunotherapy using checkpoint inhibitors is providing significant benefit to patients with renal cell carcinoma (RCC), both in overall survival and tolerability of treatment. Given the recent approval of the first checkpoint inhibitor in RCC, this review discusses the background and clinical data for checkpoint inhibition in RCC. Areas covered This review introduces and discusses the basic biologic mechanisms of checkpoint inhibitor function and focuses on the current evidence in clinical trials for the use of immunotherapy in RCC. Expert commentary Immunotherapy has been a mainstay of therapy in RCC but the recent approval of nivolumab with ORR of 25% and durable responses has provided a transformative new therapeutic option.

show abstract

Spontaneous regression of renal cell carcinoma lung metastases in a patient with psoriasis

Cited by 20 publications

References 9 publications

Diagnostic Biopsy Does Not Commonly Induce Intratumoral CD8 T Cell Infiltration in Merkel Cell Carcinoma

Diagnostic Biopsy Does Not Commonly Induce Intratumoral CD8 T Cell Infiltration in Merkel Cell Carcinoma

Biopsy-Proven Transitional Cell Carcinoma of a Lung Mass Without an Urothelial Origin - A Rare Case Report

PD-1/PD-L1 blockade in renal cell cancer

Contact Info

Product

Resources

About