Spontaneous regression of solitary osteochondromas in children: An option to consider in clinical practice

Abstract

Osteochondromas are neoplasm that belong to the family of cartilaginous histogenesis tumors and represent 90% of all forms of exostoses. As most osteochondromas are asymptomatic, underdiagnosis is frequent. Symptomatic forms usually manifest before the age of 20 years, and the most common symptoms are pain and the detection of a bony mass. Herein, we report four cases of spontaneous regression of solitary osteochondromas in the light of literature. We consider that orthopedic surgeons should take into account the possibility of spontaneous regression of these tumors, before recommending surgery. Symptoms are usually mild and we recommend following these patients with X-ray and physical examination annually.

Spontaneous resolution of proximal humerus sessile osteochondroma: A report of case and literature review

“…[8][9][10] Studies have shown that osteochondromas account for 35% of benign tumors and 10% of primitive bone cancers, making them the most common benign tumors. [2][3][4] Additionally, Kitsoul et al found that isolated osteochondroma formed at the humerus 26%, femur 30%, and tibia 43%. 11 In a study by Stitzman-Wengrowicz, the age range of patients with osteochondroma was 5-15 years, with an average age of 8.8 years.…”

“…Studies have shown that osteochondromas account for 35% of benign tumors and 10% of primitive bone cancers, making them the most common benign tumors 2–4 . Additionally, Kitsoul et al.…”

Thin Cartilage Cap May Be Related to the Spontaneous Regression in Pediatric Patients with Osteochondroma

“…At the time of initial presentation, the thickness of the cartilage cap on the MRI was related to tumor shrinkage. Spontaneous regression of solitary osteochondromas is a rare phenomenon [ 6 , 11 ]. The precise mechanism of spontaneous osteochondroma resolution is unknown.…”

“…Durán-Serrano et al reviewed 32 patients with spontaneously regressed solitary osteochondroma [ 11 ]. They found fourteen cases of the distal femur and five cases of proximal humeral osteochondroma regressions likely to occur in the proximal tibia.…”

“…However, the spontaneous regression of osteochondroma is poorly understood. Paling [ 10 ] describes the first case of spontaneously vanishing osteochondroma, and since then, a few spontaneous regressions of osteochondromas have been reported [ 11 ]. Although the exact mechanism of spontaneous regression is unknown, osteochondroma regression can occur either before or after growth plate closure via gradual absorption of the tumor stalk [ 12 ].…”