1986
DOI: 10.1172/jci112525
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Spontaneous release of interleukin 2 by lung T lymphocytes in active pulmonary sarcoidosis is primarily from the Leu3+DR+ T cell subset.

Abstract: The inflammation within the lower respiratory tract of individuals with pulmonary sarcoidosis is dominated by large numbers of helper T lymphocytes that proliferate and spontaneously release interleukin 2 (IL-2). To identify the lymphocyte subpopulation that releases IL-2 in this disorder, lung lymphocytes recovered by bronchoalveolar lavage were characterized using the mono-

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Cited by 127 publications
(80 citation statements)
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“…Consistent with previous published data (19,20), IL-2 concentrations were significantly elevated in sarcoid ELF compared with the normal group with values of 2717 Ϯ 1130 vs 1319 Ϯ 561 pM ELF, respectively ( p ϭ 0.0211). In addition to IL-2, a classical Th1 cytokine, both IL-12 p40 and IFN-␥ levels were also significantly elevated in the sarcoid group compared with normals (24,44,45).…”
Section: Th1 Cytokine and Il-18 Levels In Normal And Sarcoid Elfsupporting
confidence: 92%
“…Consistent with previous published data (19,20), IL-2 concentrations were significantly elevated in sarcoid ELF compared with the normal group with values of 2717 Ϯ 1130 vs 1319 Ϯ 561 pM ELF, respectively ( p ϭ 0.0211). In addition to IL-2, a classical Th1 cytokine, both IL-12 p40 and IFN-␥ levels were also significantly elevated in the sarcoid group compared with normals (24,44,45).…”
Section: Th1 Cytokine and Il-18 Levels In Normal And Sarcoid Elfsupporting
confidence: 92%
“…The diagnosis of pulmonary sarcoidosis was established in 20 individuals using previously defined criteria, including intrathoracic biopsy (1,5,10). The average age was 36±4 yr (range 26-56)2; there were 7 males and 13 females; 17 were nonsmokers, and 3 were current smokers.…”
Section: Methodsmentioning
confidence: 99%
“…The etiology of sarcoidosis is unknown, but all available evidence suggests it results from an exaggerated cellular immune response to unknown stimuli, in which activated T cells direct the accumulation of macrophages and subsequent granuloma formation (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13).…”
Section: Introductionmentioning
confidence: 99%
“…3 The lung is commonly affected, with lymphocyte accumulation, principally of the CD4+ phenotype, and inflammatory cytokines release. 8,9 Bronchoalveolar lavage (BAL) studies have disclosed prominent activation of alveolar macrophages and T cells, with a predominant Th1 cytokine profile. 10,11 The inflammatory response is characterized by increased production of proinflammatory cytokines, including interleukin (IL)-2, interferon (IFN-g), tumour necrosis factor (TNF)-a, interleukin IL1b, interleukin (IL)-6, and chemokines that amplify the inflammatory process and recruit monocytes from the periphery.…”
Section: Introductionmentioning
confidence: 99%