Spontaneous Remission in Localized Diffuse Large B-cell Lymphoma

Tamas, Laszlo B.; Sári, Eszter; Répássy, Gábor; Szabó, Péter M.; Bagdi, Enikő; Krenács, László; Demeter, Judit

doi:10.1007/s12253-011-9379-6

Cited by 17 publications

(8 citation statements)

References 24 publications

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“…Again he assumed that the surgery (and the subsequent inflammation) stimulated/ triggered the host immune response and eliminated the rest of the tumor cells. Spontaneous remission has also been frequently observed in patients with concomitant viral infections, such as human immunodeficiency virus and Epstein-Barr virus [31,32]. Interestingly, our patient has HIV and HCV infection, which could serve as a plausible mechanism for regression.…”

Section: Immune Response Mechanismmentioning

confidence: 59%

Untitled

2019

Int J Cancer Clin Res

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Objective/Background: Diffuse large B-cell lymphoma (DLBCL) rarely occurs in the liver. Spontaneous regression of this tumor is extremely rare. We are reporting the first case of hepatic DLBCL, and we are reviewing the English literature for cases of spontaneous regression of DLBCL and cancer in general. Methods: A 60-year-old gentleman with a history of HIV and HCV infections presented with an incidental liver mass. He was diagnosed with DLBCL germinal cell type with high grade features based on the results of pathological/cytogenetics studies. He started HCV and HIV medication but refused lymphoma chemotherapy. Results: Radiological follow up during a four-year period showed a spontaneous regression of his liver mass to a non-detectable size. Review of the English literature revealed 18 cases of DLBCL spontaneous regression, none of which were found in the liver. Here, two mechanisms are proposed to explain this phenomenon; the immunologic and the genetic. Conclusion: Chemoimmunotherapy is recommended for all DLBCL patients. However, this case of DLBCL spontaneous regression in an HIV and HCV positive patient offers a rare platform to understand the immune and genetic mechanisms for cancer and lymphoma in particular.

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Section: Immune Response Mechanismmentioning

confidence: 59%

Untitled

2019

Int J Cancer Clin Res

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“…This has been documented in primary cutaneous DLBCL of the leg, as well as DLBCL of the bladder, breast, and conjunctiva . Extranodal onset may confer a greater likelihood of spontaneous regression . One case series found that regression is more likely to occur if there is a decrease in the size of the mass within the first two weeks after biopsy, which may be a predictor of spontaneous regression …”

Section: Discussionmentioning

confidence: 98%

“…Although commonly seen in nodal areas, DLBCL can occur in essentially any tissue of the body and is typically lethal within two years of diagnosis without treatment . Spontaneous regression is a rare but documented phenomenon that is more common in low grade phenotypes Primary non‐Hodgkin lymphoma of the bone is also rare, accounting for 5% of extranodal lymphoma and less than 1% of non‐Hodgkin's lymphoma .…”

Section: Discussionmentioning

confidence: 99%

Spontaneous resolution of untreated diffuse large B‐cell lymphoma of maxillary bone after incisional biopsy

Flatow‐Trujillo

Khine

Jencks

et al. 2019

Clinical Case Reports

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“…Ferritin, sIL-2R, and LDH are all elevated in malignant lymphoma [8]. Indeed, elevation of LDH is one of the worst prognostic factors for EBV-positive DLBCL of the elderly [3].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly

et al. 2013

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A 94-year-old female patient presented with anorexia and left axillar lymphadenopathy on admission. Her past history was angina pectoris at 83 years of age and total gastrectomy due to gastric cancer at 87 years. The family history revealed that her son had had a malignant lymphoma, the histopathological diagnosis of which was diffuse large B-cell lymphoma. A physical examination showed both cervical, axillar, and inguinal lymphadenopathy without tenderness. She had elevated lactate dehydrogenase, ferritin, and soluble interleukin-2 receptor (sIL-2R). Whole-body computed tomography confirmed the cervical, axillary, and inguinal lymphadenopathy. Gallium-68 imaging revealed positive accumulation in these superficial lymph nodes. A right inguinal lymph node biopsy showed features of Epstein-Barr virus-associated lymphoproliferative disorder. Immunohistological studies on this lymph node biopsy showed CD20-positive large cells, CD3-positive small cells, and CD30-partly-positive large cells. In situ hybridization showed Epstein-Barr virus-positive, LMP-partly-positive, and EBNA2-negative cells. She refused chemotherapy as her son had died from hematemesis during chemotherapy. She received intravenous hyperalimentation for 1 month after admission. No palpable lymph nodes were identified by physical examination or computed tomography 3 months after admission, and regression of lactate dehydrogenase, ferritin, and sIL-2R was observed. She recovered from anorexia and was discharged. She died from pneumonia 10 months later after initial symptoms of anorexia. The autopsy showed no superficial lymphadenopathy.

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Spontaneous Remission in Localized Diffuse Large B-cell Lymphoma

Cited by 17 publications

References 24 publications

Untitled

Untitled

Spontaneous resolution of untreated diffuse large B‐cell lymphoma of maxillary bone after incisional biopsy

Spontaneous Remission of Epstein-Barr Virus-Positive Diffuse Large B-Cell Lymphoma of the Elderly

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