Spontaneous remission of acute leukemia after the termination of pregnancy

Mayolo, Jorge Antunez de; Ahn, Yeon S.; Temple, J. Donald; Harrington, William J.

doi:10.1002/1097-0142(19890415)63:8<1621::aid-cncr2820630830>3.0.co;2-0

Cited by 33 publications

(3 citation statements)

References 11 publications

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“…However, no clear link between spontaneous remission and infection or immune response was reported in at least one case [10]. In another report spontaneous remission was detected after termination of pregnancy [30].…”

Section: Clinical Remission and Relapse As Two States Of Hematopoiesimentioning

confidence: 98%

“…Spontaneous remission of acute myeloid leukemia is almost always transient event, with a mean duration in the literature of 7.7 months (range 1-36) [14]. In a typical case of spontaneous remission the full restoration of normal hematopoiesis and disappearance of blast cells occur in patient with acute leukemia and concurrent infection [2,7,12,16,23,27,31,32,33,36,45], blood transfusion [2,14,25,36,38] or cytokine injection [19,44]. The underlying molecular mechanisms of spontaneous remission are still unknown.…”

Section: Spontaneous Remission Of Leukemiamentioning

confidence: 99%

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Lorenz System in Thermodynamical Modelling of Leukemia Malignancy

Alexeev

2015

Preprint

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Graphical solutions of ordinary differential equations for simplified processes of heat flow in fluids (Lorenz system) and an idea of common mathematical description are the basis for the presented thermodynamical leukemia model. The model provides description of normal hematopoiesis in leukemia as two hierarchical states corresponding to remission and relapse. Transition between them is possible through pitchfork bifurcation which is considered as the common symmetrical mechanism for the phase space changes in leukemia. This mechanism also explains phenomenon of spontaneous remission. Cytopenia is considered as an adaptive reaction of hematopoiesis to entropy increase caused by leukemic clone. The following hypotheses are formulated: a) percentage of leukemia cell in marrow for relapse or remission criterion is not strict cut-off constant but a variable value; b) Probability of getting remission depends upon reaching bifurcation; c) Length of remission depends upon degree of eradication of leukemia cells in induction.

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Section: Clinical Remission and Relapse As Two States Of Hematopoiesimentioning

confidence: 98%

Section: Spontaneous Remission Of Leukemiamentioning

confidence: 99%

Lorenz System in Thermodynamical Modelling of Leukemia Malignancy

Alexeev

2015

Preprint

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“…Preleukemia : Another special situation is represented by myelodysplastic syndrome (MDS) diagnosed during pregnancy. Indeed, an association has been suggested between myelodysplasia and pregnancy, and a few cases of spontaneous remissions have been observed after the termination of pregnancy . However, in these cases, the disease rapidly recurred and patients subsequently died.…”

Section: Treatment Of Aml During Pregnancymentioning

confidence: 99%

Acute myeloid leukemia in the pregnant patient

Thomas

2015

European J of Haematology

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Although acute myeloid leukemia (AML) mostly occurs in older patients, it could be seen in women of childbearing age. It is therefore not surprising that in some patients, the management of AML will be complicated by a coexistent pregnancy. However, the association of leukemia and pregnancy is uncommon. Its incidence is estimated to be 1 in 75 000-100 000 pregnancies. During pregnancy, most leukemias are acute: two-thirds are myeloid and one-third are lymphoblastic. There is no standard approach for this clinical dilemma, in part because of variables such as the type of AML, the seriousness of the symptoms, and the patient's personal beliefs. In many cases, the diagnostic workup has to be altered because of the pregnancy, and often available treatments have varying risks to the fetus. While chemotherapy is reported to have some risks during the first trimester, it is admitted that it can be administered safely during the second and the third trimesters.

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Myelodysplastic syndromes presenting in pregnancy: A report of five cases and the clinical outcome

Siddiqui

Elfenbein

Noyes

et al. 1990

Cancer

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Five female patients, ranging in age between 22 and 36 years, presented with myelodysplastic syndromes during pregnancy between June 1982 and March 1987. Three of these five cases evolved into acute leukemia. A bone marrow transplant was attempted in the fourth. It is suggested that the association of myelodysplastic syndromes during pregnancy is more than coincidental and that acute leukemia evolves in a majority of these cases. Furthermore, refractory macrocytic anemias in pregnancy need to be carefully evaluated for a primary myelodysplastic state. Cancer 66:377-381,1990, HE MYELODYSPLASTIC SYNDROMES (MDS) are aT group of hematologic disorders that manifest dysplastic hematopoiesis and usually a hypercellular bone marrow. Ineffective hematopoiesis leads to hematologic failure in these syndromes. In 20% to 70% of these cases acute nonlymphocytic leukemia eventually evolve.'-3 Although MDS largely affects older individuals (70 years of age or older), no age group is spared, and in fact, 10% of the patients are younger than 40 years of age.4 Myelodysplastic syndromes may be primary when it is of unknown cause, and secondary when preceded by some known inciting event, usually exposure to chemotherapy and/or radiotherapy.' In 1982, the French-AmericanBritish (FAB) classification was introduced which has resulted in the creation of five subsets of MDS. This classification is now widely used resulting in better standardization when evaluating MDS and its evolving concepts.6At the University of Florida hospitals, five patients have been seen between 1982 and 1987 whose anemia or MDS presented initially during pregnancy. A review of the literature has revealed no information about such occurrences and their clinical behavior. The aggressive clinical

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Spontaneous remission of acute leukemia after the termination of pregnancy

Cited by 33 publications

References 11 publications

Lorenz System in Thermodynamical Modelling of Leukemia Malignancy

Lorenz System in Thermodynamical Modelling of Leukemia Malignancy

Acute myeloid leukemia in the pregnant patient

Myelodysplastic syndromes presenting in pregnancy: A report of five cases and the clinical outcome

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