2010
DOI: 10.1681/asn.2009080861
|View full text |Cite
|
Sign up to set email alerts
|

Spontaneous Remission of Nephrotic Syndrome in Idiopathic Membranous Nephropathy

Abstract: Spontaneous remission is a well known characteristic of idiopathic membranous nephropathy, but contemporary studies describing predictors of remission and long-term outcomes are lacking. We conducted a retrospective, multicenter cohort study of 328 patients with nephrotic syndrome resulting from idiopathic membranous nephropathy that initially received conservative therapy. Spontaneous remission occurred in 104 (32%) patients: proteinuria progressively declined after diagnosis until remission of disease at 14.… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
4

Citation Types

5
213
5
10

Year Published

2010
2010
2024
2024

Publication Types

Select...
8
2

Relationship

0
10

Authors

Journals

citations
Cited by 320 publications
(233 citation statements)
references
References 30 publications
5
213
5
10
Order By: Relevance
“…The 80% CR or PR rate (exact 95% CI 56% to 94%) we observed at 2 years cannot be explained by the traditional reported rate of 30% spontaneous remission in patients with MN. Spontaneous remissions are more common in women and in patients with subnephrotic-range proteinuria (31), whereas in patients with higher grades of proteinuria such as in our population, the spontaneous remission rate is lower (32). Similarly to previous reports, RTX was well tolerated with infusion reactions being the most common side effects (33).…”
Section: Discussionsupporting
confidence: 77%
“…The 80% CR or PR rate (exact 95% CI 56% to 94%) we observed at 2 years cannot be explained by the traditional reported rate of 30% spontaneous remission in patients with MN. Spontaneous remissions are more common in women and in patients with subnephrotic-range proteinuria (31), whereas in patients with higher grades of proteinuria such as in our population, the spontaneous remission rate is lower (32). Similarly to previous reports, RTX was well tolerated with infusion reactions being the most common side effects (33).…”
Section: Discussionsupporting
confidence: 77%
“…Indeed, ARB is recommended for MN. In about 30 % of the patients with MN remission occurs spontaneously [9]. After the start of treatment, proteinuria decreased in our patient; however, we cannot completely deny the possibility of spontaneous remission.…”
Section: Discussioncontrasting
confidence: 48%
“…The renal survival rate was 60 % at 20 years after diagnosis in patients with primary MN, and the renal survival rate in patients on steroid therapy was significantly higher in patients on supportive therapy alone in Japan [16], while spontaneous remission was reported to be common (32 %) in patients with primary MN with nephrotic syndrome in Spain [17], even in patients exhibiting chronic renal impairment [18]. Whether treatment with renin-angiotensin blockers or immunoglobulins other than steroids has a favorable effect on the renal prognosis of primary MN should be elucidated in future clinical studies.…”
Section: Discussion and Commentsmentioning
confidence: 96%