Spontaneous Renal Disease in Dogs

Robertson, John L.

doi:10.1177/019262338601400112

Cited by 24 publications

(10 citation statements)

References 21 publications

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“…Lymphohistiocytic infiltration, interstitial fibrosis, and swelling of glomeruli were related to the animal's age. This result supports previous studies that identified these changes as typical signs of aging in kidneys of rats and dogs [31–33].…”

Section: Discussionsupporting

confidence: 93%

Environmental cadmium induces histopathological changes in kidneys of roe deer

Beiglböck

Steineck

Tataruch

et al. 2002

Enviro Toxic and Chemistry

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Kidney samples of 224 roe deer (113 males, 111 females) aged three months to approximately nine years were collected in eastern Austria. Cadmium contents were examined and histological examinations were performed considering 11 different pathomorphological parameters. Cadmium burden was relatively high (range: 0.010-22.076 ppm) and increased with age. Females aged one to two years had higher contents than males of the same age. The culling site had no influence on cadmium load. The relation between the occurrence of histopathological changes and age, sex, origin, and cadmium concentration in 208 roe deer was tested. The frequency of vacuolic degeneration, pycnotic nuclei, caryolysis, and necrosis was related to increased cadmium levels. Increasing age correlated with lymphohistiocytic infiltration, interstitial fibrosis, and swelling of glomeruli. Pigment deposits and thickening of Bowman's capsule could be related to both cadmium and age. Furthermore, roe deer from an industrialized region showed alterations more frequently than animals from rural areas. We found no relation between morphological changes and sex. Though it remains to be established whether environmental cadmium exposure is the sole cause for the histopathological alterations observed, the results of this study indicate that chronic cadmium poisoning may be an important cofactor in the pathogenic mechanisms of renal damage in roe deer and that cadmium intoxication may be more widespread among wildlife than previously known.

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Section: Discussionsupporting

confidence: 93%

Environmental cadmium induces histopathological changes in kidneys of roe deer

Beiglböck

Steineck

Tataruch

et al. 2002

Enviro Toxic and Chemistry

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“…The rapidity of calculi development has been shown in a rat model of urolithiasis in which calculi of heterogeneous composition were induced in Fischer 344 rats in less than two weeks by exposure to terephthalic acid or dimethyl terephthalate, both of which are associated with aciduria and hypercalciuria. 100 Beagles appear less predisposed to develop bladder calculi than a number of other breeds. 468,470 Bladder calculi are occasionally reported in laboratory cynomolgus monkeys.…”

Section: Inflammation Cystitismentioning

confidence: 89%

“…100,101 A membranous form of glomerulonephritis is described where there is little or no proliferation of the mesangium but the glomerular basement membrane is thickened and may show subepithelial spikes and focal or granular immunostaining for IgG and complement C3. 100,101 A membranous form of glomerulonephritis is described where there is little or no proliferation of the mesangium but the glomerular basement membrane is thickened and may show subepithelial spikes and focal or granular immunostaining for IgG and complement C3.…”

Section: Dogmentioning

confidence: 99%

Urinary Tract

Greaves

2012

Histopathology of Preclinical Toxicity Studies

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“…C hronic kidney disease (CKD) is a major cause of morbidity and death in dogs and, given that it typically diagnosed relatively late in the course of the disease, dogs with advanced changes represent only a fraction of all dogs with CKD. 1,2 Human obesity is a risk factor for the development and progression of CKD, 3 and reducing body fat mass, either through dietary energy restriction or bariatric surgery, can reverse many of the associated clinical and nephropathologic manifestations. 4 Obesity is a common medical disorder in dogs, and can predispose to associated diseases such as osteoarthritis, respiratory disease, neoplasia, and insulin resistance.…”

mentioning

confidence: 99%

Effect of Weight Loss in Obese Dogs on Indicators of Renal Function or Disease

Tvarijonaviciute

Cerón

Holden

et al. 2012

Veterinary Internal Medicne

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Background: Obesity is a common medical disorder in dogs, and can predispose to a number of diseases. Human obesity is a risk factor for the development and progression of chronic kidney disease.Objectives: To investigate the possible association of weight loss on plasma and renal biomarkers of kidney health. Animals: Thirty-seven obese dogs that lost weight were included in the study. Methods: Prospective observational study. Three novel biomarkers of renal functional impairment, disease, or both (homocysteine, cystatin C, and clusterin), in addition to traditional markers of chronic renal failure (serum urea and creatinine, urine specific gravity [USG], urine protein-creatinine ratio [UPCR], and urine albumin corrected by creatinine [UAC]) before and after weight loss in dogs with naturally occurring obesity were investigated.Results: Urea (P = .043) and USG (P = .012) were both greater after weight loss than before loss, whilst UPCR, UAC, and creatinine were less after weight loss (P = .032, P = .006, and P = .026, respectively). Homocysteine (P < .001), cystatin C (P < .001) and clusterin (P < .001) all decreased upon weight loss. Multiple linear regression analysis revealed associations between percentage weight loss (greater weight loss, more lean tissue loss; r = À0.67, r 2 = 0.45, P < .001) and before-loss plasma clusterin concentration (greater clusterin, more lean tissue loss; r = 0.48, r 2 = 0.23, P = .003). Conclusion and Clinical Importance: These results suggest possible subclinical alterations in renal function in canine obesity, which improve with weight loss. Further work is required to determine the nature of these alterations and, most notably, the reason for the association between before loss plasma clusterin and subsequent lean tissue loss during weight management.

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Spontaneous Renal Disease in Dogs

Cited by 24 publications

References 21 publications

Environmental cadmium induces histopathological changes in kidneys of roe deer

Environmental cadmium induces histopathological changes in kidneys of roe deer

Urinary Tract

Effect of Weight Loss in Obese Dogs on Indicators of Renal Function or Disease

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