Spontaneous reports of most distressing concerns in patients with inoperable lung cancer: at present, in retrospect and in comparison with EORTC-QLQ-C30+LC13

Broberger, Eva; Tishelman, Carol; Essén, Louise von; Doukkali, Eva; Sprangers, Mirjam A. G.

doi:10.1007/s11136-007-9266-5

Cited by 16 publications

(15 citation statements)

References 28 publications

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“…'pain')wereused.The difference between symptom intensity and the subjective experienceofdistresshasalreadybeenestablished [15,16].If an evaluation of patient experiences is required (benefiting from an expert rating), then the results of the HOPE core documentationformneedtobesupplementedwithinformationfromthePO-Bado.Thenoteddifferencesbetweensymptom intensity and distress factors have an impact on clinical decisionmakingfortreatmentandsymptomcontrol.…”

Section: Correlations Between the Symptom Checklists Of The Hope Corementioning

confidence: 99%

Assessment of Distress with Physical and Psychological Symptoms of Patients in German Palliative Care Services

Neuwöhner¹,

Lindena²

2011

Onkologie

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Background: Within the framework of the nationwide Hospice and Palliative Care Evaluation (HOPE), the German Basic Documentation for Psycho-oncology (PO-Bado) was used from 2004 to 2006 as an optional module in most participating palliative care services to investigate how patient distress due to symptom burdens in different palliative care settings should be assessed and how professional interventions could be derived. Patients and Methods: The distress scores of 3,317 PO-Bado records out of a total of 6,958 consecutive participants from 3 yearly samples of HOPE were evaluated descriptively and compared with a reference sample of cancer patients from both general and university hospitals. Results: The relative values of distress from physical and psychological symptoms were 0.57 and 0.37 (maximum of 1.0), respectively. In 38.2% of the patients, professional psychosocial interventions were indicated. Compared to the reference sample of cancer patients, palliative care patients clearly showed more specific physical distress, but psychological symptoms were varied; in particular, distress from cognitive impairment, helplessness and grief showed higher intensities in palliative care patients than in the reference group. Conclusions: The PO-Bado rating scales assessed high levels of distress, particularly from physical symptoms, in palliative care patients. A large percentage of palliative care patients required professional psychosocial support.

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Section: Correlations Between the Symptom Checklists Of The Hope Corementioning

confidence: 99%

Assessment of Distress with Physical and Psychological Symptoms of Patients in German Palliative Care Services

Neuwöhner¹,

Lindena²

2011

Onkologie

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“…7 Patients most frequently reported fatigue, pain, and dyspnea as concerns causing them the most distress at both baseline and 6 months follow-up. 7 …”

Section: Free-listingmentioning

confidence: 97%

“…11,15,16,31 Overall, these four Tishelman et al 6 Broberger et al 7 Henoch et al 8 Hirakawa et al 9 Tanaka et al 10 Heedman and Strang 11 Smith et al 12 Hopwood and Stephens 13 Sarna et al 14 Brown et al 15 Lai et al 16 Broberger et al 17 Oh 18 Kuo and Ma 19 Tanaka et al 20 Tanaka et al 21 Kurtz et al 22 Lutz et al 23 Tishelman …”

Section: Symptom Intensity Vassmentioning

confidence: 99%

“…While it was not their primary purpose, six studies report on the language used to describe dyspnea. 7,15,16,26,32,33 All six studies obtain dyspnea descriptors via interviews, using words volunteered by subjects and/or words selected from a pre-existing list of breathlessness descriptors. An article by Wilcock et al is the only study to date that has investigated the language of Table 9 Most commonly reported dyspnea descriptors in the seven studies that included data on the language of breathlessness breathlessness in lung cancer patients using the "endorsed" descriptor method.…”

Section: Interviewmentioning

confidence: 99%

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Dyspnea in lung cancer patients: a systematic review

Kathiresan¹,

Clement²,

Sankaranarayanan³

2010

LCTT

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Dyspnea is a common and distressing symptom experienced by 19%-51% of patients with advanced cancer. Higher incidences are reported in patients approaching end of life. While the prevalence of dyspnea has been reported to be as frequent as pain in people with lung cancer, less attention has been paid to the distress associated with dyspnea. This review of the literature was undertaken to investigate how dyspnea has been assessed and whether breathlessness in people with lung cancer is distressing. Using a predetermined search strategy and inclusion criteria, 31 primary studies were identified and included in this review. Different outcome measures were used to assess the experience of dyspnea, with domains including intensity, distress, quality of life, qualitative sensation, and prevalence. Overall, the studies report a high prevalence of dyspnea in lung cancer patients, with subjects experiencing a moderate level of dyspnea intensity and interference with activities of daily living. Distress associated with breathing appears to be variable, with some studies reporting dyspnea to be the most distressing sensation, and others reporting lower levels of distress. However, taking into account the prevalence, intensity, and distress of dyspnea, the general consensus appears to be that the experience of dyspnea in people with lung cancer is common, with varying degrees of intensity, but involves considerable unpleasantness. Thus, if dyspnea and pain are both distressing sensations for people with lung cancer, this has potential implications for both clinical and academic areas with regards to both management strategies and further research.

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“…QoL was assessed with the EORTC Quality of Life Questionnaire (QLQ), an integrated system for assessing the health-related QoL of cancer patients [14] . In the last few years, QLQ-C30 has been used in a wide range of cancer clinical trials, by a large number of research groups; it has additionally been used in other various nontrial studies.…”

Section: Assessment Of Qolmentioning

confidence: 99%

Efficacy and Safety of the Oral Multikinase Regorafenib in Metastatic Colorectal Cancer

Cicero

Luca²,

Dieli

2017

Oncology

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Background/Aim: A clinical trial demonstrated that treatment with oral multikinase regorafenib improved overall survival (OS), progression-free survival (PFS), and disease control [García-Alfonso et al.: J Clin Transl Oncol 2016;18:1072-1081; Bertocchi et al.: J Chemother 2017;29:102-105]. In this study, we aimed to evaluate its effectiveness in Italian patients with hormone-refractory metastatic castration-resistant prostate cancer (mCRPC) progressing after chemotherapy with docetaxel plus prednisone. Materials and Methods: 60 patients were enrolled. OS has been assessed as the primary endpoint while PFS, quality of life, safety, and response rate represented secondary endpoints. Results: A modest tolerability was observed in our group showing a manageable toxicity profile and a modest objective response rate. It was associated with stable disease. A significant correlation between quality of life and OS was also noticed. Conclusions: Regorafenib has been proven to be an effective and well-tolerated therapeutic option in patients with mCRPC progressing after docetaxel plus prednisone treatment.

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Spontaneous reports of most distressing concerns in patients with inoperable lung cancer: at present, in retrospect and in comparison with EORTC-QLQ-C30+LC13

Cited by 16 publications

References 28 publications

Assessment of Distress with Physical and Psychological Symptoms of Patients in German Palliative Care Services

Assessment of Distress with Physical and Psychological Symptoms of Patients in German Palliative Care Services

Dyspnea in lung cancer patients: a systematic review

Efficacy and Safety of the Oral Multikinase Regorafenib in Metastatic Colorectal Cancer

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