Spontaneous Resolution of a Giant Congenital Melanocytic Nevus

Hogan, F.R.C.P. Daniel J.; Murphy, Fergus; Bremner, F.

doi:10.1111/j.1525-1470.1988.tb01164.x

Cited by 24 publications

(25 citation statements)

References 17 publications

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“…5). 25,26 The most common reported global changes in CMN are hypertrichosis and decrease in pigmentation. 27 Focal changes can also occur; however, any focal change developing within CMN should be viewed with suspicion.…”

Section: Clinical Features Natural History and Symptomsmentioning

confidence: 99%

Congenital melanocytic naevi

2009

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Congenital melanocytic naevi, consisting of clusters of naevo-melanocytes, develop in utero. Although many congenital naevi are visible at birth, some may not become evident until later in life. The timing of naevo-melanocyte proliferation, senescence and melanogenesis may all contribute towards determining when a naevus will become clinically manifest on the skin. Besides the fact that congenital melanocytic naevi may be aesthetically displeasing, resulting in a multitude of psychosocial issues, they also increase the risk for developing cutaneous melanoma, leptomeningeal melanoma, neurocutaneous melanocytosis, malformations of the brain and, rarely, other tumours such as rhabdomyosarcoma and liposarcoma. Whereas the risk of developing malignancy in association with congenital naevi is dependent, to some extent, on the size of the naevus, the risk of developing neurocutaneous melanocytosis correlates best with the number of satellite naevi. Management of patients with congenital melanocytic naevi requires individualization, taking into account the naevus size and location, and the risk of developing cutaneous melanoma or neurocutaneous melanocytosis. When contemplating treatment options, it is important to set realistic expectations and to address the possible aesthetic and functional outcomes, while at the same time addressing the risk for developing cutaneous and/or extracutaneous melanoma.

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Section: Clinical Features Natural History and Symptomsmentioning

confidence: 99%

Congenital melanocytic naevi

2009

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“…There are, however, two reports documenting spontaneous resolution of CMN. 7,8 More detailed information on the natural history of these lesions would be of help to parents and guardians of affected children in making decisions about management. Here, we report the evolution of CMN on the scalps of 5 children who presented consecutively to the pigmented lesion clinic in Leeds over a 5-year period.…”

mentioning

confidence: 99%

Spontaneous involution of congenital melanocytic nevi of the scalp

Strauss

Newton-Bishop

2008

Journal of the American Academy of Dermatology

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“…[4] The nevus cells in the halo nevus may be monoclones of aberrant cells, and the halo phenomenon may represent vigorous host response against these aberrant clones. [6] The occasional association of halo nevus with melanoma has led to the hypothesis that cytotoxic T cells acting against melanoma cells also attack nevocellular cells sharing common antigenic determinants with melanoma cells. [4] Halo phenomenon may be due to loss of melanin synthesis and/or apoptosis of melanocytes.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of a congenital melanocytic nevus

Nath¹,

Thappa²,

Ganesh³

2011

Indian J Dermatol Venereol Leprol

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Congenital melanocytic nevus (CMN) may rarely regress which may also be associated with a halo or vitiligo. We describe a 10-year-old girl who presented with CMN on the left leg since birth, which recently started to regress spontaneously with associated depigmentation in the lesion and at a distant site. Dermoscopy performed at different sites of the regressing lesion demonstrated loss of epidermal pigments first followed by loss of dermal pigments. Histopathology and Masson-Fontana stain demonstrated lymphocytic infiltration and loss of pigment production in the regressing area. Immunohistochemistry staining (S100 and HMB-45), however, showed that nevus cells were present in the regressing areas.

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Spontaneous Resolution of a Giant Congenital Melanocytic Nevus

Cited by 24 publications

References 17 publications

Congenital melanocytic naevi

Congenital melanocytic naevi

Spontaneous involution of congenital melanocytic nevi of the scalp

Spontaneous regression of a congenital melanocytic nevus

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