Spontaneous resolution of lichen myxoedematosus

Abstract

Lichen myxoedematosus was diagnosed in a 44-year-old woman in 1957. Despite the persistence of an abnormal serum protein, the skin lesions cleared by 1965. The protein abnormality disappeared several years later.

Self-healing juvenile cutaneous mucinosis

“…14 Although lichen myxedematosus usually runs a protracted, unremitting course, exceptional cases of spontaneous resolution have been reported. [15][16][17] Interestingly, the 29-year-old patient described by Kwon et al 17 presented with lichenoid skin lesion on the back of his hands, extensor surfaces, and periorbital region, common sites of involvement in SHJCM. Stephens et al 18 also reported spontaneous resolution of papular mucinosis in a patient with associated carpal tunnel syndrome.…”

Intravenous immunoglobulins control scleromyxoedema

“…The encouraging results obtained in our three cases mimic the good results obtained previously in other rheumatic diseases such as dermatomyositis, Still's disease, systemic lupus erythematosus, and vasculitides. [6][7][8][9][10] In autoimmune diseases, IVIg treatment may have additional effects, such as the modulation of immunological reactivity and of inflammatory reactions with different mechanisms of action. However, it is difficult to speculate on the mechanism that led to the improvement of our patients.…”

“…Anti-idiotypic antibodies may bind and down regulate the B cell receptor for antigen, may eventually bind to T cells regulating their function, and may have an immunomodulatory action by FcR blockade. 6 Cytokines derived from macrophages or activated T cells can exert a direct cytotoxic effect on many tissues. IVIg contains specific high affinity antibodies against interleukins (IL1α and IL6) and tumour necrosis factor α (TNFα), thus suppressing the continuing immune response in different disorders.…”

“…4 5 Scleromyxoedema is a chronic condition and rarely improves spontaneously. 6 The therapeutic approach to it is still disappointing and mortality is high. Different treatments have been suggested, with discrepant results (table 1).…”

Self-Healing Localized Cutaneous Mucinosis

“…A case of lichen myxedematosus [2] regressed 11 years after its onset. Again, lesions were multiple and parapro teinemia was present.…”