Spontaneous Resolution of Optic Disk Pit Maculopathy in a Child After a Six-Year Follow-Up

Benatti, Eleonora; Garoli, Elena; Viola, Francesco

doi:10.1097/icb.0000000000000815

Cited by 9 publications

(11 citation statements)

References 9 publications

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“…A conservative approach with closer follow-up should be advocated as reported earlier in children. 18,19 Optic disc pits are classically small and most commonly located temporally as noted in this series. The fluid from the disc pit first accumulates within the retinal stroma, most predominantly in the outer plexiform layer.…”

Section: Discussionmentioning

confidence: 56%

Treatment outcomes of optic disc pit maculopathy over two decades

Oli

Balakrishnan

2021

Ophthalmol Eye Dis

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Aim: To study the long-term outcomes of optic disc pit maculopathy. Methods: Electronic medical records of 154 patients with optic disc pit were reviewed and 50 patients with optic disc pit maculopathy who met the study criteria were included in the study. Demographic profile of patients, along with clinical characteristics, optical coherence tomography (OCT) features and change in best-corrected visual acuity (BCVA) was recorded. Patients were treated either by observation, barrage laser alone or pars plana vitrectomy (PPV) with optional additional surgical procedures. The primary outcome measures were the change in BCVA and resolution of fluid on OCT. Results: The mean age of patients was 29.96 years (3–62 years) with a follow-up of 27.16 months. The mean baseline BCVA in observation, laser and vitrectomy group was log MAR 0.94, 0.76 and 0.87 and final BCVA was log MAR 0.9, 0.67 and 0.46, respectively. There was a statistically significant improvement in the final BCVA and reduction in subretinal fluid with resolution of the schisis cavity in vitrectomy group than in other groups. On regression analysis significant association was found between final BCVA with baseline BCVA ( R2 = 0.815, p = 0.002), use of C3 F8 endotempanode ( p = 0.004) ILM peeling ( p = 0.012) and use of triamcinolone (TA; p = 0.003). No significant association was found with juxtapapillary endolaser ( p = 0.062). Conclusions: In patients with disc pit maculopathy, PPV lead to better functional and anatomical outcomes as compared to laser or observation alone. Use of surgical adjuvants like ILM peeling, TA and C3F8 tamponade improved the outcomes, unlike juxtapapillary endolaser treatment.

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Section: Discussionmentioning

confidence: 56%

Treatment outcomes of optic disc pit maculopathy over two decades

Oli

Balakrishnan

2021

Ophthalmol Eye Dis

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“…Maculopathy is a well described condition occurring in 25–75% of patients with ODP and being responsible for significant vision loss in up to 65% of the patients [ 1 , 4 , 9 – 11 ]. Macular changes described are serous detachment, cystoid degeneration, degenerative pigmentary changes and macular schisis [ 1 , 6 – 8 , 12 ]. Even though some reports describe spontaneous resolution in about 25% of patients, the majority have a poor visual prognosis with 80% of patients reporting a visual acuity of 20/200 or worse [ 4 , 6 , 7 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

“…Macular changes described are serous detachment, cystoid degeneration, degenerative pigmentary changes and macular schisis [1,[6][7][8]12]. Even though some reports describe spontaneous resolution in about 25% of patients, the majority have a poor visual prognosis with 80% of patients reporting a visual acuity of 20/ 200 or worse [4,6,7,13].…”

Section: Discussionmentioning

confidence: 99%

“…Optic disc pit (ODP) is a rare congenital defect of the optic nerve characterized by a grayish oval depression at the optic disc, most frequently found at the inferotemporal region [1][2][3][4][5][6][7][8]. Even though maculopathy has been reported to be triggered after childbirth, there are no known factors that might precipitate or are associated with worsening optic disc maculopathy [4].…”

Section: Introductionmentioning

confidence: 99%

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Optic nerve pit maculopathy worsened during pregnancy: a case report

Torrado-Cobian

Fivgas

2021

BMC Ophthalmol

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Background To report a case of Optic Disc Pit (ODP) maculopathy exacerbated during pregnancy. Case presentation A 30-year-old female developed unilateral blurry vision at 10-weeks gestation. Ophthalmic examination revealed left eye reduced visual acuity (VA) with the presence of subretinal fluid temporal to the disc extending to the fovea. On Spectral Domain Optical Coherence Tomography (SD-OCT) subretinal, and intraretinal fluid was confirmed. Laser photocoagulation was tried in an attempt to prevent surgical intervention without success; subsequently, pars plana vitrectomy, internal limiting membrane peel and gas tamponade was performed. Three-weeks later, a full thickness macular hole developed, and repeat surgery was performed. Nine-months after the second surgery the macular hole was closed with near complete resorption of edema. Conclusions No trigger factors for ODP maculopathy have been reported before. We report a case of worsening ODP maculopathy during pregnancy with good visual outcome after surgical intervention.

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“…As for the treatment options for ODP maculopathy, observation is a reasonable choice, especially in children, as spontaneous resolution has been reported 10 …”

Section: Discussionmentioning

confidence: 99%

A new mutation in the PAX2 gene in a Papillorenal Syndrome patient

Rachwani-Anil

Rocha‐de‐Lossada

Ayala

et al. 2019

American Journal of Ophthalmology Case Reports

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PurposeTo present a new mutation in a patient with Papillorenal Syndrome (PAPRS).ObservationsPAPRS is an autosomal dominant disease that involves ocular and renal abnormalities. We present a patient with PAPRS with a genetically diagnosed PAX2 and new pathogenic mutation. A complete ophthalmological, neurological, nephrological and Ears-Nose-Throat (ENT) examination were undertaken. The patient suffered from Focal Segmental Glomerulosclerosis (FSGS) and some typical ophthalmological signs of PAPRS, including optic nerve coloboma and optic disc pit (ODP) maculopathy associated with an abnormal retinal vessel distribution and numerous cilioretinal arteries in the right eye. The left eye showed similar vessel abnormalities although the optic disc had a normal morphology.ConclusionsA new mutation in the PAX2 gene was identified in a patient with ocular and renal abnormalities.

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Spontaneous Resolution of Optic Disk Pit Maculopathy in a Child After a Six-Year Follow-Up

Cited by 9 publications

References 9 publications

Treatment outcomes of optic disc pit maculopathy over two decades

Treatment outcomes of optic disc pit maculopathy over two decades

Optic nerve pit maculopathy worsened during pregnancy: a case report

A new mutation in the PAX2 gene in a Papillorenal Syndrome patient

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