Spontaneous resolution rate of grade 1 cervical intraepithelial neoplasia in a private practice population

Falls, R

doi:10.1016/s0002-9378(99)70548-x

Cited by 23 publications

(15 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Human papillomavirus (HPV) infection has been considered to be the main cause of CIN and cancer (1)(2)(3)(4), as well as one of the most common sexually transmitted diseases in the world (5)(6)(7). HPV-DNA has been detected in almost 100% of pre-neoplastic and neoplastic cervical lesions (8).…”

Section: Introductionmentioning

confidence: 99%

p16INK4 expression in precursor lesions of squamous cell cervical cancer related to the presence of HPV-DNA

Godoy

Mandelli

Oliveira

et al. 2008

Braz J Med Biol Res

View full text Add to dashboard Cite

The purpose of the present study was to identify the expression of p16 INK4 in cervical cancer precursor lesions by immunohistochemistry and to correlate it with lesion grade and presence of human papillomavirus (HPV) infection. Cervical specimens from 144 women seen consecutively at the gynecology outpatient clinic of our institution from December 2003 to May 2005 were analyzed by cytopathology, histopathology, polymerase chain reaction for HPV-DNA, and p16 INK4 immunostaining. Histologically normal biopsies, HPV-DNA negative by polymerase chain reaction, were used as control. HPV-DNA prevalence, including the control group, was 68.1% and the prevalence of p16 INK4 expression was 55.0%. The percentage of cells stained by p16 INK4 ranged from 10 to 100%, both in the group consisting of cervical intraepithelial neoplasia (CIN)1/HPV specimens and in the group of CIN2/CIN3 specimens with P value of 0.0001. p16 INK4 expression was 48.3% in the CIN1/HPV group, as opposed to 94.3% in the CIN2/CIN3 group (P = 0.001), showing a statistically significant difference between the two groups. The quantitative method used here is simple and less subjective than the different semiquantitative methods described in the literature. In view of the different definitions of a p16 INK4 -positive case, it is almost impossible to compare the findings reported by different investigators. This study confirms the association between p16 INK4 and CIN2 and CIN3 lesions. Moreover, it shows that some low grade lesions expressed high levels of this protein. This may indicate that such low grade lesions may be predisposed to progress to high grade lesions. This means that p16 INK4 may be a strong marker for "neoplastic lesions" induced by HPV and not just an infection marker.

show abstract

Section: Introductionmentioning

confidence: 99%

p16INK4 expression in precursor lesions of squamous cell cervical cancer related to the presence of HPV-DNA

Godoy

Mandelli

Oliveira

et al. 2008

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…2,11,12 Most cases of regression occur within 2 years. 2,11,12 In the present study, 60.4% of CIN1 cases regressed spontaneously without any treatment, and most regressions occurred within 1 year (90.9% of regression cases).…”

Section: Discussionmentioning

confidence: 99%

Human Papillomavirus L1 Capsid Protein and Human Papillomavirus Type 16 as Prognostic Markers in Cervical Intraepithelial Neoplasia 1

Choi¹,

Kang²,

Kim³

et al. 2010

International Journal of Gynecological Cancer

View full text Add to dashboard Cite

show abstract

“…Each year in the United States approximately 2% of cytology smears are classified as LSIL [25••]. As with ASCUS, the reproducibility of LSIL is poor and 70% to 80% of these lesions regress spontaneously without treatment [26]. Since referral to colposcopy can be anxiety inducing as well as costly, improving the positive predictive value of LSIL would also be beneficial.…”

Section: Triage Of Equivocal or Borderline Cytologymentioning

confidence: 99%

Will new human papillomavirus diagnostics improve cervical cancer control efforts?

Kulasingam

Koutsky

2001

Curr Infect Dis Rep

View full text Add to dashboard Cite

With the causal link between specific types of human papillomavirus (HPV) and cervical cancer firmly established, efforts have turned to assessing the relative merits of offering HPV testing in screening, triage, and posttreatment management. Many unanswered questions remain, but a growing body of evidence supports a role for HPV testing in cervical cancer prevention programs. Already, clinical centers that serve thousands of women in Europe and the United States have incorporated HPV DNA tests in triage algorithms.

show abstract

Spontaneous resolution rate of grade 1 cervical intraepithelial neoplasia in a private practice population

Cited by 23 publications

References 4 publications

p16INK4 expression in precursor lesions of squamous cell cervical cancer related to the presence of HPV-DNA

p16INK4 expression in precursor lesions of squamous cell cervical cancer related to the presence of HPV-DNA

Human Papillomavirus L1 Capsid Protein and Human Papillomavirus Type 16 as Prognostic Markers in Cervical Intraepithelial Neoplasia 1

Will new human papillomavirus diagnostics improve cervical cancer control efforts?

Contact Info

Product

Resources

About