2023
DOI: 10.3390/medicina59030427
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Spontaneous Reversal of Vitiligo, a Rare Phenomenon Reported in a Case in Saudi Arabia with an Insight into Metabolic Biochemical Derangements

Abstract: Background and Objectives: Vitiligo is a skin disorder characterized by hypopigmented macules occurring due to melanocyte destruction. An interplay of several biochemical mechanisms has been proposed to explain the etiopathogenesis of vitiligo, such as genetic, autoimmune responses, generation of inflammatory mediators, oxidative stress, and melanocyte detachment mechanisms. There is no cure for vitiligo; however, pharmacological treatment measures (cosmetic camouflage creams, steroids, psoralen and ultraviole… Show more

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Cited by 3 publications
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“…However, specific treatment may be requested since the cosmetic impairment is associated with a severe worsening in the quality of life: curcumin-based treatment could be evaluated here as a safe and useful approach. Moreover, the onset of vitiligo is also a rarely reported adverse event in patients with psoriasis treated with monoclonal antibodies against IL17, such as ixekizumab, but further insight into the mechanisms underlying this potential side effect is required to support this peculiar association [7].…”
mentioning
confidence: 99%
“…However, specific treatment may be requested since the cosmetic impairment is associated with a severe worsening in the quality of life: curcumin-based treatment could be evaluated here as a safe and useful approach. Moreover, the onset of vitiligo is also a rarely reported adverse event in patients with psoriasis treated with monoclonal antibodies against IL17, such as ixekizumab, but further insight into the mechanisms underlying this potential side effect is required to support this peculiar association [7].…”
mentioning
confidence: 99%