Spontaneous splenic rupture due to Babesia microti infection: Case report and review of the literature

Usatii, Natalia; Khachatrian, A B; Stratidis, John

doi:10.1016/j.idcr.2014.08.002

Cited by 10 publications

(3 citation statements)

References 10 publications

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“…are intraerythrocytic protozoan parasites and the causative agents of babesiosis, an important emerging infectious disease worldwide [ 49 ]. It is a multisystemic disease with a spectrum of manifestations ranging from subclinical disease to severe illness and death [ 50 ]. In particular, splenectomised individuals are at high risk of fatal outcome [ 36 , 51 ].…”

Section: Introductionmentioning

confidence: 99%

Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens

Stegmüller,

Qi,

Torgerson

et al. 2023

PLoS ONE

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Ticks play an important role in transmitting many different emerging zoonotic pathogens that pose a significant threat to human and animal health. In Switzerland and abroad, the number of tick-borne diseases, in particular tick-borne encephalitis (TBE), has been increasing over the last few years. Thus, it remains essential to investigate the pathogen spectrum of ticks to rapidly detect emerging pathogens and initiate the necessary measures. To assess the risk of tick-borne diseases in different regions of Switzerland, we collected a total of 10’286 ticks from rural and urban areas in ten cantons in 2021 and 2022. Ticks were pooled according to species, developmental stage, gender, and collection site, and analyzed using next generation sequencing (NGS) and quantitative polymerase chain reaction (qPCR). The metagenomic analysis revealed for the first time the presence of Alongshan virus (ALSV) in Swiss ticks. Interestingly, the pool-prevalence of ALSV was higher than that of tick-borne encephalitis virus (TBEV). Furthermore, several TBEV foci have been identified and pool prevalence of selected non-viral pathogens determined.

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Section: Introductionmentioning

confidence: 99%

Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens

Stegmüller,

Qi,

Torgerson

et al. 2023

PLoS ONE

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“…Unlike Plasmodium species, intraerythrocytic cycles of Babesia including their invasion, growth, division, and egress are still not fully understood. Apart from that, development stages of Babesia presents similar morphological features to those of Plasmodium falciparum (P. falciparum) [7,8], and Babesia patients usually presents with malaise, fever, fatigue, and headache and sometimes accompanied with hemolytic anemia and thrombocytopenia similar to malaria symptoms [13]. Such similarities have been challenging clinical diagnosis and management of the two diseases.…”

Section: Introductionmentioning

confidence: 99%

Ring stage classification of Babesia microti and Plasmodium falciparum using optical diffraction 3D tomographic technique

Mazigo

Jun

et al. 2022

Preprint

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Background: Babesia is an intraerythrocytic parasite that has always been misdiagnosed to malaria parasite, rendering to inappropriate treatment of the disease especially in co-endemic areas. Unlike Plasmodium species, intraerythrocytic cycles of Babesia including their invasion, growth, division, and egress are still not fully understood. In recent years, optical diffraction tomography (ODT) has shown great potential in the field of pathogen detection by virtue quantification of three-dimensional imaging tomograms. Methods: The early ring stage of P. falciparum and B. microti were obtained from the infected patients during diagnosis. The ODT technique was applied to analyze and characterize detailed differences at the single cell level between P. falciparum and B. microti ring stage. Based on three-dimensional quantitative information, accurate measurement was performed in morphological, biochemical, and biophysical parameters. Results: Accurate measurements indicated actual differences in morphological parameters in which the host cell surface area at the ring stage in B. microti was significantly smaller than P. falciparum, and sphericities showed higher levels in B. microti parasitized cells. Based on biochemical parameters, host cell hemoglobin level significantly increased and membrane fluctuation were more active fluctuating in P. falciparum than B. microti infected cells. The result indicates that P. falciparum more actively altered host RBCs. Conclusion: Although P. falciparum and B. microti showed often confusable characteristics under the microscopy, the actual three-dimensional properties are different. These differences could be used in differential clinical diagnosis of erythrocytes infected with B. microti and P. falciparum.

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“…Hemolytic anemia and thrombocytopenia may be accompanied. If severe, organ dysfunction, mental change, pulmonary edema, renal failure, and splenic rupture can be present [3,4].…”

Section: Introductionmentioning

confidence: 99%

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea

Kwon

Park

et al. 2018

Korean J Parasitol

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Babesiosis, caused by Babesia microti and B. divergens, is transmitted by Ixodid ticks. Symptoms of babesiosis vary from a mild flu-like illness to acute, severe, and sometimes fatal and fulminant disease. In Korea, 7 imported babesiosis cases and 1 endemic case have been reported. We report 2 cases of severe babesiosis initially mistaken as malaria. The first patient was complicated by shock and splenic infarction, the other co-infected with Lyme disease. As the population traveling abroad increases every year, physicians should be aware of babesiosis which mimics malaria, co-infection with other diseases, and its complications.

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Spontaneous splenic rupture due to Babesia microti infection: Case report and review of the literature

Cited by 10 publications

References 10 publications

Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens

Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens

Ring stage classification of Babesia microti and Plasmodium falciparum using optical diffraction 3D tomographic technique

Two Imported Cases of Babesiosis with Complication or Co-Infection with Lyme Disease in Republic of Korea

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