Spontaneous Squamous Cell Carcinoma of the Tongue and Multiple Bronchioloalveolar Carcinomas in a Virginia Opossum (Didelphis virginiana)

Kim, Dae Y.; Mitchell, Mark A.; Heras, M. De las; Taylor, Hermon; Cho, D.-Y.

doi:10.1053/jcpa.2001.0530

Cited by 5 publications

(11 citation statements)

References 8 publications

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“…Significant fibrosis was only reported previously in 1 case. 14 The number of neoplasms with concurrent inflammation or fibrosis both in our study and in the literature may suggest an inflammatory component to these neoplasms. It is interesting to note that opossums in captivity and wild-caught opossums 14,20 both have the propensity to develop pulmonary neoplasms given that environmental conditions differ.…”

supporting

confidence: 57%

“…14 The number of neoplasms with concurrent inflammation or fibrosis both in our study and in the literature may suggest an inflammatory component to these neoplasms. It is interesting to note that opossums in captivity and wild-caught opossums 14,20 both have the propensity to develop pulmonary neoplasms given that environmental conditions differ. Pulmonary neoplasms were implicated as the cause of clinical signs and resulting death or euthanasia in only 1 opossum, in our study, which is similar to previous reports.…”

supporting

confidence: 57%

“…Pulmonary neoplasms were implicated as the cause of clinical signs and resulting death or euthanasia in only 1 opossum, in our study, which is similar to previous reports. 14,20 In our study, more females than males were documented with pulmonary adenocarcinomas, but this may reflect a submission bias, as, in the previous report, there was no sex bias. 20 Dogs and cats are the most common domestic animals to develop pulmonary neoplasms (~1% of dogs autopsied at veterinary schools) and these animals are typically older.…”

mentioning

confidence: 43%

“…5 Additionally, the neoplasms in the previous study were often only observed microscopically and not on gross examination, which may have led to the benign diagnosis. 20 Multiple bronchioloalveolar carcinomas were previously reported in 1 opossum, 14 pulmonary adenocarcinomas were observed in 2 additional opossums, 2,16 and a pulmonary squamous cell carcinoma was previously documented in 1 opossum. 21 In our study, inflammation, primarily lymphocytic, was observed in 7 of 9 cases, and fibrosis was observed in 7 of 9 cases.…”

mentioning

confidence: 93%

“…Further investigation into an infectious or environmental cause, mutation, or other commonality may be warranted given the propensity of both captive and wild-caught opossums to develop multiple pulmonary tumors. 2,14,16,20 …”

mentioning

confidence: 99%

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Spontaneous neoplasms in captive Virginia opossums (Didelphis virginiana): a retrospective case series (1989–2014) and review of the literature

Pope

2017

J VET Diagn Invest

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This retrospective project summarizes the types of neoplasms identified in Virginia opossums ( Didelphis virginiana) presented to the University of Tennessee, College of Veterinary Medicine (UTCVM) postmortem service in 1989–2014 and serves as a review of the literature. Of the 85 Virginia opossums identified from the UTCVM case database, there were 17 diagnoses of neoplasia from 12 cases (14%). These cases included 8 females, 2 males, and 2 neutered males. All opossums with known ages (11 of 12) were >2 y old. Pulmonary tumors, specifically minimally invasive or lepidic-predominant adenocarcinomas, were the most common diagnosis and accounted for 53% (9 of 17) of the neoplasms. Additional tumors included acute myeloid leukemia with eosinophil maturation, hepatic hemangiosarcoma, sarcoma (unknown origin), squamous cell carcinoma, disseminated mast cell tumor, trichoblastoma, thyroid adenoma, and an osteoma. These findings serve as a reference for the types of spontaneous neoplasms in Virginia opossums; based on these findings, neoplasia should be considered as a differential in mature captive Virginia opossums.

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supporting

confidence: 57%

supporting

confidence: 57%

mentioning

confidence: 43%

mentioning

confidence: 93%

mentioning

confidence: 99%

See 3 more Smart Citations

Spontaneous neoplasms in captive Virginia opossums (Didelphis virginiana): a retrospective case series (1989–2014) and review of the literature

Pope

2017

J VET Diagn Invest

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Lingual Sarcoma and its Treatment with Partial Glossectomy in a Pet Rabbit (Oryctolagus Cuniculus)

Bulliot

Flenghi

Levrier

2019

Journal of Exotic Pet Medicine

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Lifetime cancer prevalence and life history traits in mammals

Boddy

Abegglen

Pessier

et al. 2020

Evolution, Medicine, and Public Health

126

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Cancer is a common diagnosis in many mammalian species, yet they vary in their vulnerability to cancer. The factors driving this variation are unknown, but life history theory offers potential explanations to why cancer defense mechanisms are not equal across species. Here we report the prevalence of neoplasia and malignancy in 37 mammalian species, representing 11 mammalian orders, using 42 years of well curated necropsy data from the San Diego Zoo and San Diego Zoo Safari Park. We collected data on life history components of these species and tested for associations between life history traits and both neoplasia and malignancy, while controlling for phylogenetic history. These results support Peto’s paradox, in that we find no association between lifespan and/or body mass and the prevalence of neoplasia or malignancy. However, a positive relationship exists between litter size and prevalence of malignancy (p=0.005, Adj. R2=0.212), suggesting that a species’ life history strategy may influence cancer vulnerabilities. Lastly, we tested for the relationship between placental invasiveness and malignancy. We find no evidence for an association between placental depth and malignancy prevalence (p=0.618, Adj. R2=0.068). These findings provide insight into the relationship between life history traits and cancer vulnerabilities, which suggest a trade-off between reproduction and cancer defenses. Lay Summary Comparative oncology

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Spontaneous Squamous Cell Carcinoma of the Tongue and Multiple Bronchioloalveolar Carcinomas in a Virginia Opossum (Didelphis virginiana)

Cited by 5 publications

References 8 publications

Spontaneous neoplasms in captive Virginia opossums (Didelphis virginiana): a retrospective case series (1989–2014) and review of the literature

Spontaneous neoplasms in captive Virginia opossums (Didelphis virginiana): a retrospective case series (1989–2014) and review of the literature

Lingual Sarcoma and its Treatment with Partial Glossectomy in a Pet Rabbit (Oryctolagus Cuniculus)

Lifetime cancer prevalence and life history traits in mammals

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