Spontaneous symmetrical giant keloids at the bilateral labia majora: a case report

Abstract

Keloids are caused by an imbalance between collagen matrix decomposition and production during wound repair. Spontaneous keloids are a rare type of keloid that arise without a significant history of trauma or surgery. We herein report a case involving a 59-year-old woman with symmetric neoplasms at the bilateral labia majora that had persisted for about 3 years and a >10-year history of pruritus and pain at the bilateral labia majora with folliculitis. The bilateral labia majora gradually swelled and lost their normal physiological morphology. The patient was diagnosed with keloids. Under general anesthesia, the keloids were resected. The right incision was sutured directly and the left was closed using an inguinal flap. Adjuvant radiotherapy was administered after the surgery. No recurrence of the keloids was observed at the 1-year follow-up, and the patient was satisfied with the appearance of the vulvar region. This is the first report of spontaneous symmetrical giant keloids at the bilateral labia majora, and it emphasizes the importance of the effect of abnormal inflammation on keloid formation. Repairing genital defects using an inguinal flap has only a minor effect on the patient’s postoperative movement, and an ideal vulvar appearance can be achieved.

Keloid Multipel Besar pada Perempuan Asia Muda

“…9 Nonsteroidal anti-inflammatory drugs (NSAIDs), triptans, and intravenous antiemetics are used as acute therapeutic options. 10 In preventive regimens, tricyclic antidepressants (TCAs), anticonvulsants, and gabapentin are all included. Most patients benefited from amitriptyline.…”

“…16 Cushman et al discovered that patients taking either gabapentin or amitriptyline improved compared to those who did not receive treatment. 10 Alamat Korespondensi email: setiayuda21@gmail.com PENDAHULUAN Penyembuhan luka kulit merupakan respons kompleks terhadap cedera kulit. Deregulasi proses ini dapat menyebabkan pembentukan bekas luka yang abnormal, seperti keloid.…”

“…5 Keloid menjadi masalah karena memiliki dampak fungsional, estetika, dan memengaruhi kualitas hidup pasien. 9,10 Keloid dapat terjadi pada semua kelompok umur dengan insiden tertinggi pada usia 11-30 tahun. 1 Dari 100 juta kejadian jaringan parut yang berkembang setiap tahun, 11 juta akan menjadi keloid.…”

“…8 Pertumbuhan keloid biasanya diawali dari trauma, luka bakar, luka pasca-operasi, ataupun peradangan. 10 Keloid yang tumbuh spontan adalah keloid yang berkembang tanpa riwayat trauma atau pembedahan, sangat jarang, dan umumnya dipicu oleh mikrotrauma atau peradangan kulit minimal pada pasien yang rentan secara genetik. 9,10 Beberapa laporan menunjukkan keterkaitan kondisi keloid spontan dengan berbagai sindrom, seperti sindrom Rubinstein-Tabyi, sindrom Dubowitz, sindrom Noonan, dan sindrom Goeminne.…”

Successful treatment of Giant keloid on the right toes using trepanation combined with superficial radiotherapy (SRT-100): a case report with literature review

“…Keloids are a benign fibroproliferative disorder that impairs the quality of life of patients by causing cosmetic disfigurement, pain, and pruritus ( 1 , 2 ). Keloids can occur in any part of the human body, especially in the lower jaw, chest, back, and frequently moving joint areas ( 3 ). Hypertrophic keloids affect the normal appearance of the human body and limit normal joint function.…”