Spontaneous termination of ventricular fibrillation

Calabrò, Maria Pia; Luzza, F; Carerj, Scipione; Oreto, Giuseppe

doi:10.1136/hrt.2003.012823

Cited by 11 publications

(10 citation statements)

References 19 publications

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“…For example, Torsade de Pointes is a type of arrhythmia that usually terminates after a variable number of beats from several to several hundred [540, 541]. VF is generally lethal but episodes of spontaneous termination have also been observed clinically [15, 542–545] (e.g., the case shown in Fig.2), and in experiments [405, 546]. Spontaneous termination of atrial fibrillation is widely observed [547, 548].…”

Section: Control and Termination Of Arrhythmiasmentioning

confidence: 99%

Nonlinear and stochastic dynamics in the heart

et al. 2014

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In a normal human life span, the heart beats about 2 to 3 billion times. Under diseased conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster and irregular rhythms, called arrhythmias, which may lead to sudden death. The transition from a normal rhythm to an arrhythmia is a transition from regular electrical wave conduction to irregular or turbulent wave conduction in the heart, and thus this medical problem is also a problem of physics and mathematics. In the last century, clinical, experimental, and theoretical studies have shown that dynamical theories play fundamental roles in understanding the mechanisms of the genesis of the normal heart rhythm as well as lethal arrhythmias. In this article, we summarize in detail the nonlinear and stochastic dynamics occurring in the heart and their links to normal cardiac functions and arrhythmias, providing a holistic view through integrating dynamics from the molecular (microscopic) scale, to the organelle (mesoscopic) scale, to the cellular, tissue, and organ (macroscopic) scales. We discuss what existing problems and challenges are waiting to be solved and how multi-scale mathematical modeling and nonlinear dynamics may be helpful for solving these problems.

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Section: Control and Termination Of Arrhythmiasmentioning

confidence: 99%

Nonlinear and stochastic dynamics in the heart

et al. 2014

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“…For the LR1 model, V was perturbed as (4) where V 0 (x,y) is the transmembrane potential of the prestored spiral waves and ξ(x,y) is a uniformly distributed random number in [0,1] for the location (x,y) and only applied at time 0. Similarly, for the Bär model, both variables were perturbed as (5) Because of the chaotic nature of spiral wave breakup, this perturbation results in very different fibrillation patterns (41), which then affect T s . Figure 1B shows how such random perturbations cause very different fibrillation patterns in a homogeneous 2-D tissue with the LR1 model.…”

Section: Fibrillation Durationmentioning

confidence: 99%

Critical mass hypothesis revisited: role of dynamical wave stability in spontaneous termination of cardiac fibrillation

Qu¹

2006

American Journal of Physiology-Heart and Circulatory Physiology

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The tendency of atrial or ventricular fibrillation to terminate spontaneously in finite-sized tissue is known as the critical mass hypothesis. Previous studies have shown that dynamical instabilities play an important role in creating new wave breaks that maintain cardiac fibrillation, but its role in self-termination, in relation to tissue size and geometry, is not well understood. This study used computer simulations of two-and three-dimensional tissue models to investigate qualitatively how, in relation to tissue size and geometry, dynamical instability affects the spontaneous termination of cardiac fibrillation. The major findings are as follows: 1) Dynamical instability promotes wave breaks, maintaining fibrillation, but it also causes the waves to extinguish, facilitating spontaneous termination of fibrillation. The latter effect predominates as dynamical instability increases, so that fibrillation is more likely to self-terminate in a finite-sized tissue. 2) In two-dimensional tissue, the average duration of fibrillation increases exponentially as tissue area increases. In three-dimensional tissue, the average duration of fibrillation decreases initially as tissue thickness increases as a result of thickness-induced instability but then increases after a critical thickness is reached. Therefore, in addition to tissue mass and geometry, dynamical instability is an important factor influencing the maintenance of cardiac fibrillation.

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“…Furthermore, we noticed that ventricular fibrillation could recover to sinus rhythm itself. There have been few cases presented with self-terminating ventricular fibrillation (TVF) without electric defibrillation or medical managements in clinical practice according to previous studies [11].…”

Section: Discussionmentioning

confidence: 98%

Double hazards of ischemia and reperfusion arrhythmias in a patient with variant angina pectoris

Yang

2015

Journal of Electrocardiology

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Spontaneous termination of ventricular fibrillation

Cited by 11 publications

References 19 publications

Nonlinear and stochastic dynamics in the heart

Nonlinear and stochastic dynamics in the heart

Critical mass hypothesis revisited: role of dynamical wave stability in spontaneous termination of cardiac fibrillation

Double hazards of ischemia and reperfusion arrhythmias in a patient with variant angina pectoris

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