Spontaneous Testicular Tubular Hypoplasia/Atrophy in the Göttingen Minipig

Thuilliez, Céline; Tortereau, Antonin; Perron-Lepage, Marie-France; Howroyd, Paul; Gauthier, B.

doi:10.1177/0192623313512430

Cited by 11 publications

(15 citation statements)

References 12 publications

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“…In the minipig, there is a high incidence of hypospermatogenesis and hypoplasia/atrophy of tubules during the peripubertal period, and these findings, despite being morphologically different, are lumped under the single term tubular hypoplasia/atrophy (Bode et al, ; Thuilliez et al, ; Helke et al, ). The reason for lumping these two findings under one morphologic term is likely because they represent a morphologic continuum that often occur concurrently in the same testis.…”

Section: Testesmentioning

confidence: 99%

Comparative Aspects of Pre‐ and Postnatal Development of the Male Reproductive System

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Ziejewski

Stanislaus

2017

Birth Defects Research

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This review describes pre- and postnatal development of the male reproductive system in humans and laboratory animals, and highlights species differences in the timing and control of hormonal and morphologic events. Major differences are that the fetal testis is dependent on gonadotropins in humans, but is independent of such in rats; humans have an extended postnatal quiescent period, whereas rats exhibit no quiescence; and events such as secretion by the prostate and seminal vesicles, testicular descent, and the appearance of spermatogonia are all prenatal events in humans, but are postnatal events in rats. Major differences in the timing of the developmental sequence between rats and humans include: gonocyte transformation period (rat: postnatal day 0-9; human: includes gestational week 22 to 9 months of age); masculinization programming window (rat: gestational day 15.5-17.5; human: gestational week 9-14); and mini-puberty (rat: 0-6 hr after birth; human: 3-6 months of age). Endocrine disruptors can cause unique lesions in the prenatal and early postnatal testis; therefore, it is important to consider the differences in the timing of the developmental sequence when designing preclinical studies as identification of windows of sensitivity for endocrine disruption or toxicants will aid in interpretation of results and provide clues to a mode of action. Birth Defects Research 110:190-227, 2018. © 2017 Wiley Periodicals, Inc.

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Section: Testesmentioning

confidence: 99%

Comparative Aspects of Pre‐ and Postnatal Development of the Male Reproductive System

Picut

Ziejewski

Stanislaus

2017

Birth Defects Research

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“…Seminiferous tubular atrophy, Leydig cell hyperplasia, and epididymal atrophy were observed by histopathological examination in male animals older than 20 months of age. Tubular atrophy has been reported to occur in the testis with a high incidence in younger Göttingen minipigs (64.4% at 4–5 months of age, 87.0% at 6–10 months of age, and 86.4% at 10–15 months of age) 12 . Therefore, we consider that seminiferous tubular atrophy is a common finding in the testis of both CLAWN miniature swine and Göttingen minipigs.…”

Section: Discussionmentioning

confidence: 99%

Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation

et al. 2017

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The aim of this study was to identify potential changes that could occur during histological evaluations of CLAWN miniature swine, with potential consequences for subsequent experiments. The systemic organs from male and female CLAWN miniature swine (16.3–42.3 months old) that had been used in long-term studies of coronary stent implantation were examined histologically. Commonly observed histopathological findings were testicular/epididymal atrophy, cyst-like follicles in the ovaries, hemosiderin deposition in the spleen, lipofuscin deposition in the proximal tubular epithelia and presence of eosinophilic globules in the Bowman’s space and the lumen of the proximal tubules in the kidneys, and cellular infiltration in several organs, including the eyelids, respiratory organs, and digestive tract. However, none of these changes were serious enough to indicate a significant impact on research. In conclusion, this study identified CLAWN miniature swine as a suitable animal model for various experiments.

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“…Terminology such as prepuberty, puberty, and early adult do not correspond precisely with a determination of sexually immature and sexually mature, and this is because the transitions through these stages are gradual and difficult to pinpoint. Also, there is inconsistency in the literature concerning the use of terminology (Table 2; Bode et al 2010;DeNoon 2012;Dreef, Van Esch, and De Rijk 2007;FDA 2006;Goedken, Kerlin, and Morton 2008;Haruyama et al 2012;Helke et al 2016aHelke et al , 2016bHirsch et al 1985;Howroyd 2015;Howroyd, Peter, and de Rijk 2016;Jorgensen et al 1998;Lanning et al 2002;Marty et al 2003;Navratil et al 2014;Ojeda and Skinner 2006;Parker 2011;Sengupta 2013;Smedley et al 2002;Smidt 1970;Stoker et al 2000;Svendsen 2006;Takakura et al 2014;Thuilliez et al 2014). A distinction must also be made between the onset of puberty and puberty itself.…”

Section: Evaluating Testis In Immature Large Animalsmentioning

confidence: 99%

Impact of Age on the Male Reproductive System from the Pathologist’s Perspective

Picut

Remick

2016

Toxicol Pathol

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Age, and in particular young age, can significantly impact the response to toxicants in animals and can greatly influence the interpretation of tissue changes by the toxicologic pathologist. Although this applies to multiple organ systems, the current review focuses on the male reproductive system. When performing microscopic evaluation of male reproductive organs, the toxicologic pathologist must be aware of the dynamic changes in histomorphology, predominantly driven by timed hormonal alterations, at various life stages. Specific challenges pathologists face are understanding the appearance of male reproductive tissues throughout the neonatal, infantile, and juvenile developmental periods, recognizing when normal looks abnormal during tissue development, defining sexual maturity, and working with high interanimal variability in maturation rate and histologic appearance in developing large laboratory animals, such as nonhuman primates, dogs, and pigs. This review describes postnatal development of the male reproductive system in the rat, demonstrates how assessing toxicity during a defined window of postnatal development in the rat may improve definition of toxicant timing and targets, and discusses challenges associated with the interpretation of toxicity in immature large animal species. The emphasis is on key age-related characteristics that influence the interpretation of tissue changes by the toxicologic pathologist.

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Spontaneous Testicular Tubular Hypoplasia/Atrophy in the Göttingen Minipig

Cited by 11 publications

References 12 publications

Comparative Aspects of Pre‐ and Postnatal Development of the Male Reproductive System

Comparative Aspects of Pre‐ and Postnatal Development of the Male Reproductive System

Histopathological background data of the systemic organs of CLAWN miniature swine with coronary artery stent implantation

Impact of Age on the Male Reproductive System from the Pathologist’s Perspective

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