2019
DOI: 10.7759/cureus.4679
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Spontaneous Tumor Lysis Syndrome in Diffuse Large B-cell Lymphoma: Early Diagnosis and Management

Abstract: Spontaneous tumor lysis syndrome is a rare oncological emergency associated with multiorgan failure. It is characterized by an elevation of uric acid, hyperphosphatemia, hypocalcemia, hyperkalemia and renal failure in the setting of no active chemotherapy as a result of lysis of massive tumor burden. Early recognition of the disease and prompt management would affect morbidity and mortality. We present the case of an 80-year-old Caucasian male with a history of recently diagnosed diffuse large B-cell lymphoma … Show more

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Cited by 15 publications
(25 citation statements)
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“…Spontaneous tumor lysis syndrome occurs rarely but has fatal consequences. Clinicians should be wary about the intrinsic and extrinsic risk factors with special attention to malignancies with a high proliferation rate [15].…”
Section: Discussionmentioning
confidence: 99%
“…Spontaneous tumor lysis syndrome occurs rarely but has fatal consequences. Clinicians should be wary about the intrinsic and extrinsic risk factors with special attention to malignancies with a high proliferation rate [15].…”
Section: Discussionmentioning
confidence: 99%
“…С другой стороны, развитие синдрома острого лизиса опухоли могло произойти в связи с хирургическим воздействием (повышение внутрибрюшного давления, манипу-ляции в ходе биопсии) [10]. Но не стоит забывать и о синдроме спонтанного опухолевого лизиса при ЛБ, описанном в литературе [11][12][13][14]. Провести адекватную интенсивную терапию с привлечением методов заместительной почечной терапии оказалось возможно в условиях реанимации и интенсивной терапии.…”
Section: обсуждение результатов исследованияunclassified
“…TLS occurs in 5%-20% of malignancies, typically occurring 48-72 hours after patients with high-grade rapidly proliferating hematologic malignancies initiate chemotherapy or targeted therapy [1]. Much less frequently, patients may have spontaneous TLS with a similar constellation of disturbances, which has been observed in aggressive lymphomas such as Burkitt's lymphoma and with acute leukemias with markedly elevated cell counts [2]. Here we describe a case of spontaneous TLS from multiple myeloma, which is unusual in that it is considered an indolent hematologic malignancy.…”
Section: Introductionmentioning
confidence: 99%