Spontaneous Tumours in Captive African Hedgehogs (Atelerix albiventris):a Retrospective Study

Raymond, James T.; Garner, Michael M.

doi:10.1053/jcpa.2000.0441

Cited by 122 publications

(138 citation statements)

References 11 publications

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“…21,22 In summary, 2 subcutaneous spindle cell sarcomas consistent with malignant peripheral nerve sheath tumor and a vaginal spindle cell sarcoma are described in this report. With the exception of an undifferentiated subcutaneous sarcoma, 22 soft tissue sarcomas have not been reported in hedgehogs. Sarcomas involving bone have been described in hedgehogs in which retrovirus particles were found.…”

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confidence: 71%

“…Cutaneous squamous cell carcinoma, mast cell tumor, pituitary adenoma, myelogenous leukemia, sarcomas, intestinal lymphosarcoma, intestinal plasmacytoma, renal transitional cell carcinoma, hepatic adenoma, oral carcinoma, poorly differentiated subcutaneous sarcoma, subcutaneous neurofibroma, and mammary neoplasms have been reported. 3,4,10,14,17,19,[20][21][22][23][24] Microscopically, both cutaneous tumors had features of neurofibrosarcoma. 11 Neurofibrosarcomas are also called neurogenic sarcoma, malignant schwannoma, and more recently, malignant peripheral nerve sheath tumor (MPNST).…”

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confidence: 99%

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Soft Tissue Sarcomas in the African Hedgehog (Atelerix Albiventris): Microscopic and Immunohistologic Study of Three Cases

Ramos-Vara

2001

J VET Diagn Invest

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Abstract. Three soft tissue tumors from 2 female hedgehogs were examined microscopically and immunohistochemically. Two tumors involved haired skin and the third one was vaginal. Microscopically, the cutaneous tumors had features of malignant peripheral nerve sheath tumor (MPNST), whereas the vaginal tumor was classified only as a spindle cell sarcoma. Immunohistochemically, all 3 tumors were strongly positive for vimentin and strongly to moderately positive for CD10 and neuron-specific enolase but did not stain with antibody to S100 protein, an antigen typically present in human MPNST. The cutaneous tumor from hedgehog no. 1 was examined ultrastructurally and the neoplastic cells resembled fibroblasts. Hedgehog no. 1 was euthanized at the time of the biopsy. The outcome of the other hedgehog was unknown.African hedgehogs (Atelerix albiventris) are popular exotic pets. Consequently, there is demand for information regarding their husbandry and diseases. 22 Neoplastic diseases constitute approximately 30% of the histopathologic diagnoses made in hedgehogs. 22 A search of the Veterinary Medical Diagnostic Laboratory (VMDL), Columbia, MO, database (1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000) found 40 accessions of hedgehogs with histopathologic exam. Sixty-three percent of the cases were nonneoplastic, 37% were neoplastic. This report describes the morphologic and immunohistochemical features of 3 spindle cell sarcomas in 2 African hedgehogs. Case no. 1 was a 4.5-month-old female African hedgehog, which developed a mass on the medial aspect of the right foreleg. The hedgehog was euthanized at the owner's request. The 3-cm-diameter mass and multiple organs were collected by the referring veterinarian for histopathologic examination at the VMDL. Case no. 2 was a 3-year-old female African hedgehog with a mass in the right lumbar skin and another mass in the vagina, which were excised and sent to the VMDL for histopathologic examination.Tissues were fixed for an undetermined period in 10% buffered formalin and embedded in paraffin. Five-micrometer sections were stained with HE and Masson trichrome. For immunohistochemistry, paraffin sections were placed on positively charged slides and stained with antibodies to vimentin, a smooth muscle-specific actin, a muscle-specific actin, a desmin, a CD10, b S100 protein, a neuron-specific enolase, a chromogranin A, a synaptophysin, a glial fibrillary acidic protein, a and factor VIII-related antigen a following described methods. 18 Immunohistochemical staining was performed in From the Veterinary

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confidence: 71%

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confidence: 99%

Soft Tissue Sarcomas in the African Hedgehog (Atelerix Albiventris): Microscopic and Immunohistologic Study of Three Cases

Ramos-Vara

2001

J VET Diagn Invest

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“…6 Nervous system tumors were not observed. 6 In a similar study, the prevalence of neoplasia in African hedgehogs at necropsy was found to be between 29% and 53%. 3 Up to 85% of tumors in hedgehogs are malignant.…”

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confidence: 93%

“…In a study of WHS there was a 7% (3 of 45) incidence of astrocytomas at necropsy in hedgehogs that presented with clinical signs of WHS. 2 Vet Pathol 45: 6,2008 Little is known about diseases of hedgehogs, but more reports are being written about the very high incidence of neoplasia in these animals. Because many of these animals suffer from a debilitating central nervous system degenerative disease (WHS) the incidence of central nervous system neoplasia may be overlooked and some of these animals may benefit from early detection and treatment.…”

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Anaplastic Astrocytoma in the Spinal Cord of an African Pygmy Hedgehog (Atelerix albiventris)

et al. 2008

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Abstract.A 2-year-old, female hedgehog presented with an 8-month history of progressive, ascending paresis/paralysis and was tentatively diagnosed with wobbly hedgehog syndrome. She died awaiting further diagnostic tests, and the owners consented to postmortem examination. Grossly, the bladder was large and flaccid and the cervical and lumbar spinal cord were regionally enlarged, light grey, and friable with multifocal hemorrhages. The thoracic spinal cord was grossly normal. Microscopically all regions of the spinal cord had similar changes, although the cervical and lumbar sections were most severely affected. These regions were completely effaced by a moderately cellular infiltration of highly pleomorphic polygonal to spindle shaped cells, mineralization, and necrosis, which were most consistent with anaplastic astrocytoma. The thoracic spinal cord white matter was similarly infiltrated by the neoplastic cells, with perivascular extension into the otherwise normal grey matter. A diagnosis of anaplastic astrocytoma was confirmed using immunohistochemical stains that were positive for glial fibrillary acidic protein and S100.

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“…"content-markup(./ author-grp [1]/aff|./author-grp [1]/dept-list)> Neoplasms are regularly encountered in African hedgehogs (Atelerix albiventris), and a wide variety of tumors have been described in this species. 14,15 However, skeletal system neoplasms are uncommon. There is only 1 report of multicentric skeletal sarcoma in 2 African hedgehogs.…”

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Rib Osteoblastic Osteosarcoma in an African Hedgehog (Atelerix Albiventris)

et al. 2006

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Abstract.A 3-year-old African hedgehog (Atelerix albiventris) was presented to the Exotic Animal Clinic of the University of Montreal for evaluation of a mass growing on the right thoracic wall. The diagnostic workup, which included helical computed tomography, confirmed the presence of a large mass, originating from the right 7th rib, infiltrating the thoracic wall and cavity. The animal was euthanized due to the poor prognosis. At necropsy, a well-demarcated mass penetrated the thoracic wall and incorporated the 6th to 8th ribs. Cut sections of the tumor were white, glistening, firm, and gritty. Microscopically, it was composed of polyhedral to elongated cells with interspersed trabeculae of osteoid and large areas of coagulative necrosis. On the basis of histopathologic findings, a diagnosis of osteoblastic osteosarcoma was made. To the authors' knowledge, this is the first report of an osteoblastic osteosarcoma on the thoracic wall of an African hedgehog, as well as the first report of the use of helical computed tomography in that species.

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Spontaneous Tumours in Captive African Hedgehogs (Atelerix albiventris):a Retrospective Study

Cited by 122 publications

References 11 publications

Soft Tissue Sarcomas in the African Hedgehog (Atelerix Albiventris): Microscopic and Immunohistologic Study of Three Cases

Soft Tissue Sarcomas in the African Hedgehog (Atelerix Albiventris): Microscopic and Immunohistologic Study of Three Cases

Anaplastic Astrocytoma in the Spinal Cord of an African Pygmy Hedgehog (Atelerix albiventris)

Rib Osteoblastic Osteosarcoma in an African Hedgehog (Atelerix Albiventris)

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