SPOOC (Sensor for Periodic Observation of Choline): An Integrated Lab‐on‐a‐Spoon Platform for At‐Home Quantification of Choline in Infant Formula

Al‐Shami, Abdulrahman; Amirghasemi, Farbod; Soleimani, Ali; Khazaee Nejad, Sina; Ong, Victor; Berkmen, Alara; Ainla, Alar; Mousavi, Maral P.S.

doi:10.1002/smll.202311745

Cited by 9 publications

(2 citation statements)

References 66 publications

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“…In this context, the development of an electrochemical sensor for precise Baricitinib (BARI) determination represents a significant breakthrough. Electrochemical sensors offer numerous advantages, including high sensitivity, rapid response times, and cost-effectiveness. − The utilization of such a sensor enables the accurate detection and quantification of Baricitinib (BARI), facilitating real-time monitoring and personalized treatment strategies. With its reliability and precision, this electrochemical sensor serves as a valuable tool for therapeutic drug monitoring, allowing healthcare professionals to adjust dosages optimally, and ensuring the drug’s effectiveness and safety. , This innovative analytical technology paves the way for improved patient care and enhanced treatment outcomes in Baricitinib (BARI) management.…”

Section: Introductionmentioning

confidence: 99%

Toward an Improved Electrocatalytic Determination of Immunomodulator COVID Medication Baricitinib Using Multiwalled Carbon Nanotube Nickel Hybrid

Abbas,

Fayed,

Hegazy

et al. 2024

ACS Appl. Bio Mater.

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The study presents a first electrochemical method for the determination of the immunomodulator drug Baricitinib (BARI), crucial in managing COVID-19 patients requiring oxygen support. A unique electrode was developed by modifying graphite carbon nickel nanoparticles (NiNPs) with functionalized multiwalled carbon nanotubes (f.MWCNTs), resulting in nanohybrids tailored for highly sensitive BARI detection. Comparative analysis revealed the superior electrocatalytic performance of the nanohybrid-modified electrode over unmodified counterparts and other modifications, attributed to synergistic interactions between f.MWCNTs and nickel nanoparticles. Under optimized conditions, the sensors exhibited linear detection within a concentration range from 4.00 × 10–8 to 5.56 × 10–5 M, with a remarkably low detection limit of 9.65 × 10–9 M. Notably, the modified electrode displayed minimal interference from common substances and demonstrated high precision in detecting BARI in plasma and medicinal formulations, underscoring its clinical relevance and potential impact on COVID-19 treatment strategies.

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Section: Introductionmentioning

confidence: 99%

Toward an Improved Electrocatalytic Determination of Immunomodulator COVID Medication Baricitinib Using Multiwalled Carbon Nanotube Nickel Hybrid

Abbas,

Fayed,

Hegazy

et al. 2024

ACS Appl. Bio Mater.

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“…Special nanoparticle materials may be embedded in carbon paste electrodes to boost analytical sensitivity. [13][14][15][16][17][18][19][20][21][22] These techniques are implemented for the detection of the drugs present in low concentrations within biological samples, offering the advantage of minimal interference and eliminating the necessity for sample preparation. [23][24][25][26] The most common voltammetric techniques are square wave voltammetry (SWV), differential pulse voltammetry (DPV), and cyclic voltammetry (CV).…”

mentioning

confidence: 99%

Electrochemical Sensor Modified with Graphene Oxide Decorated with Copper Oxide Nanoparticles for Velpatasvir’s Monitoring in Spiked Human Plasma

Hesham,

Mahmoud,

Hegazy

et al. 2024

J. Electrochem. Soc.

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Velpatasvir, an antiviral agent co-formulated with sofosbuvir used to treat hepatitis C, has recently demonstrated beneficial therapeutic effects against COVID-19. Therefore, therapeutic drug monitoring of velpatasvir is essential to achieve the desired clinical outcomes. An electrochemical sensor modified with synthesized copper oxide nanoparticles on the surface of graphene oxide (CuO/GO-NPs) was fabricated for the analysis of velpatasvir for the first time. Characterization was carried out using Fourier-transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy with energy-dispersive X-ray spectroscopy. The voltammetric determinations were conducted using differential pulse and cyclic voltammetry, where the modified electrode exhibited better sensitivity than the unmodified one. The method was validated according to the International Council for Harmonisation (ICH) guidelines, exhibiting linearity within a range of 1.0 ×10-7 – 1.0 × 10-5 M, covering velpatasvir’s maximum plasma concentration (Cmax), with a quantification limit of 2.89 × 10-7 M and a detection limit of 9.03 × 10-8 M. The developed sensor was successfully applied to spiked human plasma at velpatasvir’s Cmax level. The method’s greenness was assessed using the Analytical Eco-scale and the Green analytical procedure index tools. This method holds promise as a green simple approach to implemented in future velpatasvir’s therapeutic drug monitoring studies.

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Designing a heavy metal electrochemical sensor for Pb detection in water—A generalized approach for electrochemical sensing using low‐cost materials

Rajesh,

Kumawat

2024

Can J Chem Eng

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This work attempts to design an elemental method for detecting heavy metals in water. The presence of heavy metals in water is a critical issue that needs a check at every level of water consumption. To facilitate the checking, a simple method needs to be identified and developed. Electrochemical sensing is essentially a surface phenomenon and requires a higher surface area for greater accuracy and reliability. We have attempted to use a readily available Cu wire for detecting Pb to 50 μM concentration with 90% reliability. It is important to note that the sensing electrode (Cu wire) utilized for this work has been employed in a facile manner that enhances the ease of use for heavy metal electrochemical sensor. Moreover, post‐usage, the replacement of sensor material for subsequent usage is easy. The low cost and simplicity of the method make it ideal for resource‐constrained environments and portability, resulting in increasing the accessibility of water quality monitoring. The study examines the reliability of a low‐cost electrode for Pb concentration detection in water samples to the concentration of 50 μM using a simple low‐cost electrochemical sensor arrangement.

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SPOOC (Sensor for Periodic Observation of Choline): An Integrated Lab‐on‐a‐Spoon Platform for At‐Home Quantification of Choline in Infant Formula

Cited by 9 publications

References 66 publications

Toward an Improved Electrocatalytic Determination of Immunomodulator COVID Medication Baricitinib Using Multiwalled Carbon Nanotube Nickel Hybrid

Toward an Improved Electrocatalytic Determination of Immunomodulator COVID Medication Baricitinib Using Multiwalled Carbon Nanotube Nickel Hybrid

Electrochemical Sensor Modified with Graphene Oxide Decorated with Copper Oxide Nanoparticles for Velpatasvir’s Monitoring in Spiked Human Plasma

Designing a heavy metal electrochemical sensor for Pb detection in water—A generalized approach for electrochemical sensing using low‐cost materials

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