Multi-frequency multi-bit programmable amplitude modulation (AM) of spoof surface plasmon polaritons (SPPs) is realized at millimeter wave frequencies with interdigital split-ring resonators (SRRs) and In-Ga-Zn-O (IGZO) Schottky diodes. Periodic SRRs on a metal line guide both SRR mode and spoof SPP mode, the former of which rejects the spoof SPP propagation at the SRR resonant frequencies. To actively modulate the amplitude of spoof SPPs, IGZO Schottky diodes are fabricated in the SRR gaps, which continuously re-configure SRRs to metallic loops by applying bias. Interdigital gaps are designed in SRRs to increase the capacitance, thus red shifting the resonant frequencies, which significantly broadens the operation bandwidth of multi-frequency AM. Thus, cascading different kinds of interdigital SRRs with Schottky diodes enables multi-frequency multi-bit AM programmable. As a demonstration, a dual-frequency device was fabricated and characterized, which achieved significant multi-bit AM from −12.5 to −6.2 dB at 34.7 GHz and from −26 to −8.5 dB at 50 GHz independently and showed programmable capability.