Sporadic colorectal carcinomas with low‐level microsatellite instability in Korea: Do they form a distinct subgroup with distinguished clinicopathological features?

Kim, Young‐Ho; Min, Byung‐Hoon; Choi, Hyo Kyung; Kim, Sue Jin; Kim, Kyoung‐Mee; Kim, Jin Yong; Chang, Dong Kyung; Son, Hee Jung; Rhee, Poong–Lyul; Kim, Jae J.; Rhee, Jong Chul; Chun, Ho-Kyung

doi:10.1002/jso.21239

Cited by 12 publications

(15 citation statements)

References 18 publications

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“…MSI assay is used as a prognostic marker for CRC. In contrast to MSI‐H CRCs with favorable prognosis (Boland et al, ), along with our results, some studies stated MSI‐L CRCs are associated with poorer OS (Garcia et al, ; Kohonen‐Corish et al, ; S. Y. Lee et al, ; Mojarad et al, ; Ok et al, ; Wright et al, ), whereas Y. H. Kim et al () did not find any significant differences and Azzoni et al () justified MSI‐L CRCs are associated with favorable oncologic outcomes.…”

Section: Discussionsupporting

confidence: 75%

“…However, the reported prevalence varies according to ethnicity, number of markers, and the panels that were used for the MSI (Azzoni et al, 2011;Kets et al, 2006;Y. H. Kim et al, 2009;Mojarad et al, 2016;Rudzki et al, 2003), our results confirmed that tumors classified as MSI-L are a distinct molecular group with different clinicopathological features, however, other studies did not support the discrimination of MSI-L from MSS tumors in clinicopathological features (Kambara et al, 2001;S.…”

Section: Discussionsupporting

confidence: 70%

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MSI‐L/EMAST is a predictive biomarker for metastasis in colorectal cancer patients

Esfahani

Seyedna

Nazemalhosseini‐Mojarad

et al. 2018

Journal Cellular Physiology

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Background Microsatellite instability (MSI) is a prognostic marker in colorectal cancer (CRC). The biological significance of MSI‐low (MSI‐L) phenotype and its differences with microsatellite stable (MSS) phenotype remains unclear. The aim of this study is indicating the role of mononucleotide repeat in identifying MSI‐L and revealing the association of MSI‐L with elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) and oncologic outcome in CRC patients. Methods MSI and EMAST status were analyzed using three quasimonomorphic panel (BAT‐25, BAT‐26, and NR‐27) and five tetranucleotide repeats (D20S82, D20S85, D9S242, D8S321, and MYCL1), respectively, by capillary electrophoresis method without the need to fluorescent primers. The associations of MSI status with clinicopathological features, EMAST status, metastasis, and overall survival (OS) were investigated. Results Among 159 CRC patient 22.0% were MSI‐H, 40.3% were MSS, 37.7% were MSI‐L, and 41.5% showed EMAST + phenotype. MSI‐L were associated with advanced stages, EMAST+ tumors and worse OS ( p ≤ 0.001). Metastasis was relatively common in MSI‐L/EMAST + CRCs and BAT‐25 were the most unstable marker in these tumors. Conclusions MSI‐L tumors have different clinicopathological features from MSS and MSI‐H tumors. The MSI‐L phenotype is a worse prognostic biomarker in CRC and when accompanied by EMAST could be a predictor for metastasis.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionsupporting

confidence: 70%

MSI‐L/EMAST is a predictive biomarker for metastasis in colorectal cancer patients

Esfahani

Seyedna

Nazemalhosseini‐Mojarad

et al. 2018

Journal Cellular Physiology

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“…Several criteria are used to define MSI. In the report by Gafa et al it is mentioned as an independent prognostic factor,60 while Kim et al could not demonstrate an effect on survival in CRC 61. Four studies on the relation between MSI and survival in MAC were included in this review.…”

Section: Discussionmentioning

confidence: 99%

“…Mucinous differentiation results in a 2–8% increased hazard of death, which persists after correction for stage. Although the relation between MAC and MSI was clearly demonstrated,10 61 65 the combined effect of MAC and MSI on survival is less studied. Our systematic search identified only four publications addressing this subject.…”

Section: Discussionmentioning

confidence: 99%

Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis

et al. 2012

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“…The prevalence of MSI in endometrial polyps was 6.4% (6/109), and all polyps were MSI-low. The biological significance of MSI-low in colorectal carcinoma has been conflicting because although MSI-low seemed to be located in the “gray zone” between MSS and MSI-high, the sporadic MSI-low displayed clinicopathological features and might form a distinct subgroup [17]. The prevalence of MSI-low in sporadic endometrial carcinoma varies between 10 and 30%, but its clinical and histopathological significance are not clear [5,15].…”

Section: Commentsmentioning

confidence: 99%

Microsatellite instability in endometrial polyps

Rios

Andrade

Pereira

et al. 2010

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective(s) To investigate the prevalence of microsatellite instability (MSI) in endometrial polyps and to evaluate whether there are clinical and histopathological parameters associated with this kind of instability. Study design Between September 2008 and April 2009, endometrial polyps were collected from 109 patients. MSI was evaluated using the NCI recommended markers BAT25, BAT26, D2S123, D5S346 and D17S250. Histopathological analysis was performed, and clinical information was obtained from patients' records. Result(s) MSI low was detected in 6.4% of the validated samples (7/109). Of the seven MSI that were detected, six were positive for instability at D17S250 and one at D5S346. There were no significant differences between polyps with or without MSI with regard to age, BMI, menarche, parity, miscarriage or menopause; however, MSI was more frequent in polyps with simple hyperplasia without atypia (3/20; 15%). Furthermore, patients with multiple polyps had a marginally but statistically insignificant increase in the frequency of MSI (p < 0.07). Conclusion(s) This is the first prospective study of MSI in endometrial polyps using hysteroscopically obtained samples. In a population of 109 patients, MSI was infrequent in endometrial polyps. Although MSI appears to be more frequent in multiple polyps and polyps with simple hyperplasia without atypia, this was not statistically significant.

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Sporadic colorectal carcinomas with low‐level microsatellite instability in Korea: Do they form a distinct subgroup with distinguished clinicopathological features?

Abstract: These results indicated that sporadic MSI-low CRCs in Korea displayed distinguished clinicopathological features and might form a distinct subgroup especially from MSS CRCs. Further large studies are required to evaluate the impact of MSI-low status on prognosis.

Cited by 12 publications

References 18 publications

MSI‐L/EMAST is a predictive biomarker for metastasis in colorectal cancer patients

MSI‐L/EMAST is a predictive biomarker for metastasis in colorectal cancer patients

Mucinous subtype as prognostic factor in colorectal cancer: a systematic review and meta-analysis

Microsatellite instability in endometrial polyps

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