Sporadic Hemangioblastoma of the Cavernous Sinus and Meckel's Cave

Valeshabad, Ali Kord; Xiao, Lekui; Amin‐Hanjani, Sepideh; Alsadi, Alaa; Vályi-Nagy, Tibor; Kim, Jinsuh

doi:10.1055/s-0038-1676455

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…According to Mills et al .,[ 26 ] 60% of patients with supratentorial hemangioblastomas are diagnosed with VHL disease or have a positive genetic study for the VHL gene mutation, which is located on the short arm of chromosome 3, position 3p25– 26. [ 39 ] Regarding the intracranial location, most are located in the cerebral hemispheres (58%), the sellar and parasellar region (26%), the cerebral ventricles (10%), and the other less frequent locations (6%), among which stand out two cases located in the Meckel’s cavum[ 20 , 34 ] and another in the choroidal fissure. [ 36 ] Hemangioblastomas located in the sellar and parasellar region are of special interest, since 87% of them are related to VHL disease.…”

Section: Discussionmentioning

confidence: 99%

Sporadic supratentorial hemangioblastoma with meningeal affection: A case report and literature review

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Claramonte

Martín

et al. 2021

Surgical Neurology International

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Background: Hemangioblastomas are vascular tumors, of benign behavior, that originate in the central nervous system. Supratentorial hemangioblastomas are extremely rare and are generally associated with Von Hippel-Lindau disease (VHL). The involvement of structures by contiguity, such as blood vessels or meninges, is something exceptional. There are few references in the literature of supratentorial hemangioblastomas with meningeal involvement and most of them are described in reports or small case series. Methods: We performed a systematic review of the literature to observe the characteristics of patients with supratentorial hemangioblastomas with meningeal involvement. In addition, we present the case of a 43-year-old male patient with a sporadic supratentorial hemangioblastoma with both, meningeal and vascular involvement that recurred years after treatment. Results: The patients presented supratentorial tumors with meningeal involvement, we had a 1.2:1 ratio male-female distribution. The mean age was 50 years. Most tumors were located in the cerebral hemispheres, the lobe affected most frequently was the frontal lobe. About 67% of the cases were sporadic and only 21% were related to VHL disease. There were three cases of recurrence after surgery. Conclusion: Supratentorial hemangioblastomas are extremely rare lesions. It is rare for supratentorial hemangioblastomas to invade adjacent structures such as blood vessels or meninges, however, when this happens, it is recommended a preoperative vascular imaging study, especially in parasagittal hemangioblastomas where superior longitudinal sinus may be involved. In these cases, en bloc surgical resection is difficult and the probability of recurrence is higher. Although clinical trials and studies with a greater casuistry are necessary to establish guidelines for the management of supratentorial hemangioblastomas, nowadays, contribution of new cases is useful for understanding this pathology.

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Section: Discussionmentioning

confidence: 99%

Sporadic supratentorial hemangioblastoma with meningeal affection: A case report and literature review

Ortega

Claramonte

Martín

et al. 2021

Surgical Neurology International

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“…If needed, the possibility for further tumor removal is given. The discussed approaches Benign Schwannoma [61] Benign melanotic schwannoma [99] Xanthoma [100] Lipoma [61] Neuromuscular hamartoma [33] Hemangioblastoma [27] Cavernous hemangioma [63] Pituitary adenoma [63] Malignant Malignant peripheral nerve sheet tumor [63] Primary Nasal glioma [25] Atypical teratoid-rhabdoid [20] Intradural chordoma [15] Chondrosarcoma [63] Paraganglioma [30] Rhabdomyosarcoma […”

Section: Decision-makingmentioning

confidence: 99%

Access to Meckel’s cave for biopsies of indeterminate lesions: a systematic review

et al. 2020

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Accessing Meckel's cave (MC) is surgically challenging. Open approaches are complex and often correlated with high morbidity. Endoscopic approaches emerged in the last decade as feasible alternatives to open approaches, especially for sampling indeterminate lesions. This article first analyses available routes to approach Meckel's cave and presents furthermore an illustrative case. We conducted a systematic review and reported according to the guidelines for preferred reporting items for systematic reviews and meta-analyses (PRISMA). Various surgical approaches identified through the search are evaluated and discussed in detail. Additionally, we report on a case of woman with a lesion in MC, which was accessed through an endoscopic transpterygoid approach subsequently diagnosed as a diffuse large B cell lymphoma. Our search delivered 75 articles that included case reports (n = 21), cadaveric studies (n = 32), clinical articles (n = 16), review of the literatures (n = 3), as well as technical notes (n = 2) and a radiological manuscript (n = 1). Open routes included lateral approaches with many variations, mainly intra-and extradural pterional approaches and anterior petrosal, as well as a retrosigmoid intradural suprameatal and a lateral transorbital approach. Endoscopically, MC was reached via approaches that included transpterygoid, transorbital or infraorbital fissure routes. Percutaneous approaches, e.g. through the foramen ovale, were also described. Multiple surgical approaches to MC are currently available. Their different characteristics as well as individual patient factors, such as clinical history and the localization of the disease, have to be considered when choosing a surgical corridor. Studies included in this review highlight the endonasal endoscopic transpterygoidal technique as an excellent corridor for biopsies in the ventral MC.

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Sporadic Hemangioblastoma of the Cavernous Sinus and Meckel's Cave

Cited by 2 publications

References 13 publications

Sporadic supratentorial hemangioblastoma with meningeal affection: A case report and literature review

Sporadic supratentorial hemangioblastoma with meningeal affection: A case report and literature review

Access to Meckel’s cave for biopsies of indeterminate lesions: a systematic review

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