Sporadic Medullary Carcinoma of the Ileum

Peycru, T.; Jarry, Julien; Soubeyran, Isabelle

doi:10.1016/j.cgh.2011.03.006

Cited by 7 publications

(11 citation statements)

References 4 publications

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“…They are almost invariably MSI‐H and are not associated with EBV . Only one case of small bowel medullary carcinoma, affecting both terminal ileum and caecum, has been reported …”

Section: Discussionmentioning

confidence: 99%

“…8,9 Only one case of small bowel medullary carcinoma, affecting both terminal ileum and caecum, has been reported. 2 Medullary carcinomas have to be differentiated from other poorly differentiated malignancies. Malignant lymphomas, in particular diffuse large B cell lymphoma (DLBCL), can be excluded easily by immunohistochemistry.…”

Section: Discussionmentioning

confidence: 99%

“…These tumours usually develop from adenomas and are found most commonly in the duodenum. The majority of tumours are adenocarcinomas and, to date, only one case of medullary carcinoma has been reported …”

Section: Introductionmentioning

confidence: 99%

“…The majority of tumours are adenocarcinomas and, to date, only one case of medullary carcinoma has been reported. 2 A major factor in the development of small bowel carcinoma is chronic inflammation. Thus, long-standing stricturing Crohn's disease has been identified as major risk factor.…”

Section: Introductionmentioning

confidence: 99%

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Medullary carcinoma of the small bowel

et al. 2016

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“…They are almost invariably MSI‐H and are not associated with EBV . Only one case of small bowel medullary carcinoma, affecting both terminal ileum and caecum, has been reported …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Medullary carcinoma of the small bowel

et al. 2016

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“…Major factors contributing to the development of medullary carcinoma include those associated with chronic underlying inflammation which was not noted in our patient. The presence of inflammatory conditions such as ulcerative colitis, celiac or Crohn's disease may serve as triggers for the development of this neoplasm [6]. The predisposition for development of medullary carcinoma in celiac disease increases with both age and delayed diagnosis due to lack of treatment [2].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Medullary Carcinoma of the Ileum

González

Sidhu

Eisner

2018

American Journal of Gastroenterology

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Medullary carcinoma of the small intestine is an exceedingly rare tumor. These tumors account for less than 0.04% of all colorectal cancers and only one case to date has been reported in the ileum. Although the clinical manifestations can be consistent with signs of intestinal obstruction, often times they are discovered incidentally in an asymptomatic patient. Major contributing risk factors to the development include long standing inflammation such as Crohn's disease, and other chronic inflammatory illnesses. Tumor markers and imaging can aid in the diagnosis, however biopsy is needed for definitive diagnosis. Despite the fact that the development of these tumors in the ileum is rare, further enhancement of awareness can aid in the appropriate early detection and appropriate treatment modalities.

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