Sporadic Shiga Toxin–Producing <i>Escherichia coli</i>–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021

Jones, Gabrielle; Mariani-Kurkdjian, Patricia; Cointe, Aurélie; Bonacorsi, Stéphane; Lefèvre, Sophie; Weill, François-Xavier; Le Strat, Yann

doi:10.3201/eid2910.230382

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…For example, Shiga-toxin-producing E. coli is a bacterium that can be found in raw or undercooked ground meat products. It can cause serious foodborne illness with symptoms such as abdominal cramps and diarrhea, with the latter sometimes progressing to bloody diarrhea (hemorrhagic colitis) [31]. In swine production, E. coli is one of the leading causes of diarrhea among newborn and weaning piglets, as it impairs the integrity of the intestinal mucosal barrier [30,32,33].…”

Section: Discussionmentioning

confidence: 99%

Effects of Gamma-Ray Irradiation of Bacteria Colonies in Animal Feeds and on Growth and Gut Health of Weaning Piglets

Wei,

Yang,

Jiang

et al. 2023

Animals

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Animal feeds contain a substantial number and diversity of microorganisms, and some of them have pathogenic potential. The objectives of this study were to investigate the effects of different doses of gamma (γ)-ray irradiation on the bacteria count in different types of feed and then to test the effect of γ-ray-irradiation-treated fishmeal on the gut health and growth performance of weaning piglets. In trial 1, three fishmeal samples, two feather meal samples, three meat meal samples, three soybean meal samples, and three vitamin complexes were treated with γ-ray irradiation doses of 0, 3, 6, or 9 kGy. The 6 and 9 kGy doses eliminated most of the bacteria in the feed but also resulted in a loss of vitamin C and B1. In trial 2, 96 weaning piglets were fed one of the following three diets with eight replicates (pens) per group over a 14-day period: (1) the control diet—the basal diet supplemented with 6% fishmeal with a low bacteria count (40 CFU/g) and no E. coli; (2) the fishmeal-contaminated diet (FM-contaminated) diet—the basal diet supplemented with 6% fishmeal with a high bacteria count (91,500 CFU/g) and E. coli contamination; and (3) the irradiated fishmeal (irradiated FM) diet—the basal diet supplemented with γ-ray-irradiation-treated E. coli-contaminated fishmeal. The piglets that received the FM-contaminated diet had significantly lower average daily gain and a greater diarrhea index compared to those fed the control diet, whereas γ-ray irradiation treatment abrogated the negative effect of the E. coli-contaminated fishmeal. Collectively, γ-ray irradiation at a dose of 6–9 kGy was sufficient to eliminate the microorganisms in the feed, thereby benefitting the growth performance and gut health of the weaning piglets.

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Section: Discussionmentioning

confidence: 99%

Effects of Gamma-Ray Irradiation of Bacteria Colonies in Animal Feeds and on Growth and Gut Health of Weaning Piglets

Wei,

Yang,

Jiang

et al. 2023

Animals

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“…STEC has emerged as a great public health concern due to the significant risk of serious and potentially lifethreatening complications of infection, e.g., HUS. It was estimated that on average, there are 2.8 million acute infections globally each year, with a greater rate of infection in children [2].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Shiga Toxin-Producing Escherichia coli Circulating in Asymptomatic Food Handlers

Sui,

Yang,

Luo

et al. 2023

Toxins

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Shiga toxin-producing Escherichia coli (STEC) is a foodborne zoonotic pathogen that causes diarrhea, hemorrhagic colitis (HC), and hemolytic uremic syndrome (HUS) worldwide. Since the infection can be asymptomatic, the circulation of STEC in some asymptomatic carriers, especially in healthy-food-related professionals, is not yet well understood. In this study, a total of 3987 anal swab samples from asymptomatic food handlers were collected, and ten swabs recovered STEC strains (0.251%). Of the ten STEC isolates, seven serotypes and eight sequence types (ST) were determined using whole genome sequencing (WGS). Two stx1 subtypes (stx1a and stx1c) and four stx2 subtypes (stx2a, stx2b, stx2d, and stx2e) were detected. Seven different insertion sites were found in fourteen Stx prophages, and the dmsB and yfhL were the newly identified insertion sites. The ten strains showed the variable Stx transcription levels after the mitomycin C induction. The whole-genome phylogeny indicated that the strains from the asymptomatic food handlers were genetically distant from the strains of HUS patients. The STEC isolates circulating in asymptomatic carriers might pose a low potential to cause disease.

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Infezioni intestinali virali e batteriche

Cassir

2024

EMC - AKOS - Trattato di Medicina

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Sporadic Shiga Toxin–Producing Escherichia coli–Associated Pediatric Hemolytic Uremic Syndrome, France, 2012–2021

Cited by 8 publications

References 27 publications

Effects of Gamma-Ray Irradiation of Bacteria Colonies in Animal Feeds and on Growth and Gut Health of Weaning Piglets

Effects of Gamma-Ray Irradiation of Bacteria Colonies in Animal Feeds and on Growth and Gut Health of Weaning Piglets

Characteristics of Shiga Toxin-Producing Escherichia coli Circulating in Asymptomatic Food Handlers

Infezioni intestinali virali e batteriche

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