Sporotrichoid-like calcinosis cutis and calcifications in vessel walls and eccrine sweat glands following intravenous infusion of calcium gluconate

Indurated, non‐tender nodules at peripheral IV sites in a newborn

“…1,3,4 Although not performed in our patient, in unclear cases, a biopsy can be performed and may show multiple, small, globular deposits in the dermis and large, dense deposits in the subcutaneous layer. 3 Diagnosis of CC in its early stages is crucial due to risk of necrosis, tissue loss, and deformity. 4 In extensive CC, more severe complications can arise such as compartment syndrome, hypercalcemia, and death secondary to infection.…”

“…The exact mechanism leading to tissue calcification is poorly understood. Local trauma or tissue damage accompanied by prolonged contact with calcium salts likely play an important role in the pathophysiology …”

“…Local trauma or tissue damage accompanied by prolonged contact with calcium salts likely play an important role in the pathophysiology. 3,4 Calcinosis cutis can be mistaken for thrombophlebitis, early cellulitis, abscess, or hematoma, especially in the presence of inflammation around the site of venipuncture and a lack of radiographic findings early in the course of the disease. [1][2][3] Diagnosis is made through history of extravasation following calcium infusion and radiologic findings of a characteristic amorphous calcific mass localized in the soft tissues.…”

“…3,4 Calcinosis cutis can be mistaken for thrombophlebitis, early cellulitis, abscess, or hematoma, especially in the presence of inflammation around the site of venipuncture and a lack of radiographic findings early in the course of the disease. [1][2][3] Diagnosis is made through history of extravasation following calcium infusion and radiologic findings of a characteristic amorphous calcific mass localized in the soft tissues. 1,3,4 Although not performed in our patient, in unclear cases, a biopsy can be performed and may show multiple, small, globular deposits in the dermis and large, dense deposits in the subcutaneous layer.…”

“…[1][2][3] Diagnosis is made through history of extravasation following calcium infusion and radiologic findings of a characteristic amorphous calcific mass localized in the soft tissues. 1,3,4 Although not performed in our patient, in unclear cases, a biopsy can be performed and may show multiple, small, globular deposits in the dermis and large, dense deposits in the subcutaneous layer. 3 Diagnosis of CC in its early stages is crucial due to risk of necrosis, tissue loss, and deformity.…”