Sport activity in Charcot–Marie–Tooth disease: A case study of a Paralympic swimmer

Vita, Giuseppe; Foresta, Stefania La; Russo, Massimo; Vita, Gian Luca; Lunetta, Christian; Mazzeo, Anna

doi:10.1016/j.nmd.2016.06.002

Cited by 16 publications

(15 citation statements)

References 19 publications

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“…Of the seven publications addressing the mental health of Paralympic athletes specifically, one examined how participation in parasport resulted in psychological, physiological and emotional changes in an elite athlete,3 one explored the role of parasport in athletes’ self-perceptions and identity development,4 and one compared mood and personality differences between elite athletes who were and were not chosen for their country’s Paralympic team 5. A study from Iran assessed the quality of working life and levels of depression in Paralympic athletes and non-athletes working together at a training institution in the country 6.…”

Section: Resultsmentioning

confidence: 99%

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Mental health symptoms and disorders in Paralympic athletes: a narrative review

et al. 2019

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ObjectivesThis narrative review summarises the literature on the mental health of Paralympic athletes, explores possible reasons for the paucity of research in this area and suggests directions for future research.MethodsA systematic search of PubMed, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, SPORTDiscus, Scopus, and Cochrane databases was conducted using search terms related to disability, sport and mental health.ResultsThe search yielded 665 publications. Of these, 129 were duplicates, resulting in 536 publications identified for initial screening. A total of 72 publications were to be relevant at initial screening. Only seven publications addressed Paralympic athletes specifically. Of these papers, three included measures of depression and three included measures of anxiety. In the studies that were not concerned with mental health symptoms or disorders, the focus of enquiry included identity and self, stress, and well-being.ConclusionMost of the studies reviewed are small in scale, and there are almost no comparative data on Paralympic versus Olympic athletes. There is a paucity of data on rates of mental health symptoms and disorders in this population and the factors that might contribute to poor mental health among elite athletes with disabilities. We propose that stereotypes about people with disabilities—and the disability rights movement’s rightful reaction to these stereotypes—have created barriers to mental health research among Paralympic athletes. There is a need for enquiry into the differential stressors experienced by Paralympic athletes, including trauma, transition out of sport, sport and personhood, and the potential for disability sport to promote psychological health.

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Section: Resultsmentioning

confidence: 99%

“…Among the included publications, there was one case study employing qualitative methods,3 three other qualitative studies with sample sizes between 5 and 23 Paralympic athletes,4 8 9 and three studies that used quantitative analyses 5–7. Study samples were drawn from Paralympic athletes in Italy, England, USA, Iran, Brazil and Australia.…”

Section: Resultsmentioning

confidence: 99%

Mental health symptoms and disorders in Paralympic athletes: a narrative review

et al. 2019

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“…The diagnosis of HCC was based on the Barcelona Consensus Statements [21] and American Association for the Study of Liver Diseases Guidelines [22] .…”

Section: Cohort Selectionmentioning

confidence: 99%

“…(21) Un estudio informa los cambios físicos y emocionales inducidos por la actividad deportiva de un nadador paraolímpico con ECMT, en el cual compararon las evaluaciones antes y después de iniciar la actividad deportiva por un periodo de 5 años encontrando mejoría en un aumento de los músculos proximales de las extremidades superiores, mayor capacidad de impulsar la silla de ruedas, mejoría en la calidad de vida, reducción de la ansiedad, depresión y mejora de autoestima. (22) En los pacientes con ECMT las contracturas musculares más frecuentes son: banda iliotibial, isquiotibiales, flexores de cadera, soleo y gemelos, aductores, tibial posterior, fascia plantar, flexores de dedos ocasionando dedos en garra. (9) Los ejercicios de fortalecimiento muscular aeróbicos moderados se debe iniciar antes de la degeneración del nervio y aumento de la debilidad muscular, las actividades de alta resistencia no son indicados por lo que se sugiere fortalecimiento regular en combinación con ejercicios acuáticos como actividad de recreación.…”

Section: -Fisioterapia Y Ejerciciounclassified

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2019

RMV

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“…Non-pharmacological enhancement of autophagy such as caloric restriction or exercise presents another way of overcoming the pharmacological modulation of other cellular pathways. Physical exercise has already been described as a rehabilitating measure in CMT patients ( Roberts-Clarke et al, 2016 ; Vita et al, 2016 ). Whether improvement of autophagy is a mediator of the positive impact of exercise remains to be investigated, but exercise has been shown to enhance autophagy in the brain ( He et al, 2012 ) and skeletal muscles ( Ferraro et al, 2014 ).…”

Section: Autophagy Modulation As a Therapeutic Target In Hereditary Nmentioning

confidence: 99%

Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies

Haidar

Timmerman

2017

Front. Mol. Neurosci.

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The inherited peripheral neuropathies (IPNs) comprise a growing list of genetically heterogeneous diseases. With mutations in more than 80 genes being reported to cause IPNs, a wide spectrum of functional consequences is expected to follow this genotypic diversity. Hence, the search for a common pathomechanism among the different phenotypes has become the holy grail of functional research into IPNs. During the last decade, studies on several affected genes have shown a direct and/or indirect correlation with autophagy. Autophagy, a cellular homeostatic process, is required for the removal of cell aggregates, long-lived proteins and dead organelles from the cell in double-membraned vesicles destined for the lysosomes. As an evolutionarily highly conserved process, autophagy is essential for the survival and proper functioning of the cell. Recently, neuronal cells have been shown to be particularly vulnerable to disruption of the autophagic pathway. Furthermore, autophagy has been shown to be affected in various common neurodegenerative diseases of both the central and the peripheral nervous system including Alzheimer’s, Parkinson’s, and Huntington’s diseases. In this review we provide an overview of the genes involved in hereditary neuropathies which are linked to autophagy and we propose the disruption of the autophagic flux as an emerging common pathomechanism. We also shed light on the different steps of the autophagy pathway linked to these genes. Finally, we review the concept of autophagy being a therapeutic target in IPNs, and the possibilities and challenges of this pathway-specific targeting.

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Sport activity in Charcot–Marie–Tooth disease: A case study of a Paralympic swimmer

Cited by 16 publications

References 19 publications

Mental health symptoms and disorders in Paralympic athletes: a narrative review

Mental health symptoms and disorders in Paralympic athletes: a narrative review

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Autophagy as an Emerging Common Pathomechanism in Inherited Peripheral Neuropathies

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