Sport and Hemophilia in Italy: An Obstacle Course

Lassandro, Giuseppe; Pastore, Carmela; Amoruso, A.; Accettura, D.; Giordano, Paola

doi:10.1249/jsr.0000000000000499

Cited by 5 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings were in agreement with previous observations and with other authors' studies, which demonstrated that the lack of knowledge and misunderstanding of the preventive effects of physical activity in hemophilia were among the main barriers to practicing sports [30][31][32]. The fear of parents was found to manifest with excessive stress in terms of the risks linked to non-recommended exercise activities [31].…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians’ Perspective

Lassandro

Accettura

Giordano

2021

IJERPH

Self Cite

View full text Add to dashboard Cite

Historically, people with hemophilia have been warned to avoid physical activities as a possible cause of bleeding; however, currently, sport is considered necessary, especially in the developmental age, for providing a good quality of life. A survey was proposed to a group of hematologists and sports physicians working in Puglia, Italy, to explore their approach to physical activities for their patients with hemophilia and to obtain suggestions about possible interventions to promote the access of patients to sports. The survey was answered by 6 hematologists and 15 sports physicians. In total, 71% (about six patients/year/physician) of patients with hemophilia seen by sports physicians asked for counseling about sports, and 67% (about five patients/year/physician) actually practiced sports. On the other hand, only 31% (about 16 patients/year/hematologist) of patients asked hematologists questions on sports, and only 16% (about seven patients/year/hematologist) of patients with hemophilia and that were followed-up by hematologists practiced sports. The sports most often recommended to patients with hemophilia by physicians included swimming, athletics, tennis, running and gymnastics. According to hematologists, physical activity was very efficient in improving the quality of life of patients; stability of joints; their psychological, social and musculoskeletal wellbeing; and in reducing the risk of bleedings. On the other hand, physical activity was considered less important in all these areas by sport physicians. In conclusion, answers to this survey suggested that sports could be promoted among hemophilic patients by increasing the sports physicians’ knowledge about hemophilia and their special role in this area. In addition, interviewed clinicians were of the opinion that increased awareness of specific guidelines and clinical practice protocols among both hematologists and sports physicians could be beneficial. Finally, answers suggested that access to fitness certification should be facilitated.

show abstract

Section: Discussionsupporting

confidence: 93%

“…Very little data existed on the activity levels of PWH in countries with limited resources [29]. In Italy, the attitude toward sports practice in PWH was discouraging in 2018 [30].…”

Section: Discussionmentioning

confidence: 99%

Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians’ Perspective

Lassandro

Accettura

Giordano

2021

IJERPH

Self Cite

View full text Add to dashboard Cite

show abstract

“…Nonacog alfa treatment was associated with low joint bleed ABRs throughout the study, similar to another study of children younger than 6 years with haemophilia B receiving nonacog alfa prophylaxis 15 . These results suggest that nonacog alfa effectively maintains a low incidence of clinically apparent joint bleeding events in young children, which has long‐term implications for joint disease 27 and may allow them to lead more active social lives 28 …”

Section: Discussionsupporting

confidence: 78%

“…15 These results suggest that nonacog alfa effectively maintains a low incidence of clinically apparent joint bleeding events in young children, which has long-term implications for joint disease 27 and may allow them to lead more active social lives. 28 These findings should be viewed with several limitations in mind. During the retrospective phase, safety and efficacy data were based on medical history; thus, data collection was limited by available information.…”

Section: Discussionmentioning

confidence: 98%

Safety and efficacy of nonacog alfa for the treatment of haemophilia B in children younger than 6 years of age in a routine clinical care setting: the EUREKIX registry study

et al. 2020

Self Cite

View full text Add to dashboard Cite

Introduction European regulatory authorities request postmarketing safety and efficacy data for factor IX (FIX) products. Aim Collect additional clinical data from routine nonacog alfa use in children aged <6 years with haemophilia B. Methods The EUREKIX registry included retrospective and prospective data collection phases. Safety was assessed via adverse drug reactions (ADRs)/adverse events (AEs) and events of special interest (ESIs) as the primary objective; efficacy was evaluated via annualised bleeding rates (ABRs). Results The retrospective phase comprised 37 subjects. Of these, 25 had severe haemophilia B. One subject experienced 2 ADRs; another experienced 4 ESIs of hypersensitivity. Median ABR in subjects receiving a predominantly on‐demand regimen (prophylaxis <50% of time; n = 11) was 2.0; median ABR was 3.8 in those receiving predominantly prophylactic treatment (prophylaxis ≥50% of time; n = 24). Joint bleeding was infrequent (median ABR, 0.4; n = 35). The prospective phase included 26 subjects, with 17 continuing from the retrospective phase. A total of 20 subjects had severe haemophilia B. Three subjects experienced 7 treatment‐related AEs; 3 experienced 4 ESIs. Median ABR was 4.5 and 1.1 in subjects who received predominantly on‐demand (n = 5) or prophylactic treatment (n = 19), respectively; the overall median ABR for joint bleeding events was 0.0. Conclusions Overall, nonacog alfa treatment effectively controlled bleeding events, with no new safety signals identified. These data support the safety and efficacy of nonacog alfa in routine clinical settings in children aged <6 years.

show abstract

“…The modifiable factors, such as a balanced diet and exercise, have an important role already in childhood. In particular, regular physical activity has a key role in bone strengthening, not only in healthy children, but also in those suffering from chronic diseases [15][16][17].…”

Section: Physiological Mechanisms Of Bone Remodelingmentioning

confidence: 99%

How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review

Faienza

Lassandro

Chiarito

et al. 2020

IJERPH

Self Cite

View full text Add to dashboard Cite

Bone remodeling is a lifelong process, due to the balanced activity of the osteoblasts (OBs), the bone-forming cells, and osteoclasts (OCs), the bone-resorbing cells. This equilibrium is mainly regulated by the WNT-ß-cathenin pathway and the RANK-RANKL/OPG system, respectively. Bone ageing is a process which normally occurs during life due to the imbalance between bone formation and bone resorption, potentially leading to osteoporosis. Bone loss associated with bone ageing is determined by oxidative stress, the result of the increasing production of reactive oxygen species (ROS). The promotion of physical exercise during growth increases the chances of accruing bone and delaying the onset of osteoporosis. Several studies demonstrate that physical exercise is associated with higher bone mineral density and lower fracture incidence, and the resulting bone mineral gain is maintained with ageing, despite a reduction of physical activity in adulthood. The benefits of exercise are widely recognized, thus physical activity is considered the best non-pharmacologic treatment for pathologies such as osteoporosis, obesity, diabetes and cardiovascular disease. We reviewed the physiological mechanisms which control bone remodeling, the effects of physical activity on bone health, and studies on the impact of exercise in reducing bone ageing.

show abstract

Sport and Hemophilia in Italy: An Obstacle Course

Cited by 5 publications

References 7 publications

Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians’ Perspective

Promoting Sports Practice in Persons with Hemophilia: A Survey of Clinicians’ Perspective

Safety and efficacy of nonacog alfa for the treatment of haemophilia B in children younger than 6 years of age in a routine clinical care setting: the EUREKIX registry study

How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review

Contact Info

Product

Resources

About