Sporulation-inducing factor inStreptomyces avermitilis

Nova, J.; Kopecký, Jan; Ванек, З.

doi:10.1007/bf02899907

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The avermectin-producing Streptomyces avermitilis possesses an inducible valine dehydrogenase

Nguyen

Béhal

1995

Biotechnol Lett

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Valine dehydrogenase (VDH) is believed to be absent in 5treptomyces avermitilis. In the present study, a VDH (M, 72 000) was detected by activity measurement and activity staining on a native-PAGE gel. The enzyme activity was induced by L-valine and repressed by ammonia. VDH activity was found to be significantly lower than L-valine transaminase activity. The results suggest that one active VDH does exist in S. avermitilis, and plays a role in valine catabolism and avermectin biosynthesis.

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