Spot-scanning proton radiation therapy for recurrent, residual or untreated intracranial meningiomas

Weber, Damien Charles; Lomax, Antony; Rutz, Hans; Stadelmann, O; Egger, Emmanuel; Timmermann, Beate; Pedroni, E.; Verwey, Jorn; Miralbell, Raymond; Goitein, Gudrun; Group, The Swiss Proton Users

doi:10.1016/j.radonc.2004.02.011

Cited by 96 publications

(42 citation statements)

References 56 publications

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“…IMPT is routinely delivered to cancer patients at PSI (Switzerland) (14,16,18). The work on development and clinical implementation of IMPT is currently under way at MGH and other proton centers in the US and internationally.…”

Section: Discussionmentioning

confidence: 99%

“…The experience with IMPT at Paul Scherrer Institut (Switzerland) demonstrated a potential for improved tissue sparing in a number of sites, including intracranial, nasopharyngeal and paraspinal lesions (14)(15)(16)(17)(18). While intensity-modulation has been identified as a means to achieve prostate dose escalation (12), IMPT treatment of prostate cancer has not yet been performed anywhere.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Radiotherapy Treatment of Early-Stage Prostate Cancer with IMRT and Protons: A Treatment Planning Comparison

Trofimov

Nguyen

Coen

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

199

163

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Purpose-To compare intensity-modulated photon radiotherapy (IMRT) with 3D-conformal proton therapy (3D-CPT) for early stage prostate cancer, and explore the potential utility of intensitymodulated proton therapy (IMPT).Methods-Ten patients were planned with both 3D-CPT (2 parallel-opposed lateral fields) and IMRT (7 equally spaced coplanar fields). Prescribed dose was 79.2 Gy (or cobalt Gray-equivalent, CGE for protons) to the prostate gland. Dose-volume histograms, dose conformity, and equivalent uniform dose (EUD) were compared. Additionally, plans were optimized for 3D-CPT with nonstandard beam configuration, and for IMPT assuming delivery with beam scanning.Results-At least 98% of the PTV received the prescription dose. IMRT plans yielded better dose conformity to the target, while proton plans achieved higher dose homogeneity, and better sparing of rectum and bladder in the range below 30 Gy/CGE. Bladder volumes receiving over 70 Gy/CGE (V 70 ) were reduced, on average, by 34% with IMRT vs. 3D-CPT, while rectal V 70 were equivalent. EUD from 3D-CPT and IMRT plans were indistinguishable within uncertainties, for both bladder and rectum. With the use of small-angle lateral-oblique fields in 3D-CPT and IMPT, the rectal V 70 was reduced by up to 35% compared to the standard lateral configuration, while the bladder V 70 increased by less than 10%.Conclusions-In the range over 60 Gy/CGE, IMRT achieved significantly better sparing of the bladder, while rectal sparing was similar with 3D-CPT and IMRT. Dose to healthy tissues in the range below 50% of the target prescription was substantially lower with proton therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Radiotherapy Treatment of Early-Stage Prostate Cancer with IMRT and Protons: A Treatment Planning Comparison

Trofimov

Nguyen

Coen

et al. 2007

International Journal of Radiation Oncology*Biology*Physics

199

163

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“…Investigators from Paul Scherrer Institute recently reported on the treatment of 16 patients with recurrent, residual, or untreated intracranial meningiomas (Weber et al, 2004). The median prescribed dose was 56 CGE (52 -64) at 1.8 -2 CGE per fraction.…”

Section: Benign Meningiomamentioning

confidence: 99%

“…Of course, the risk of second malignancy is also a risk in adults, but the fact that the median age of adult cancer patients at diagnosis is in the seventh decade, that second malignancies after radiotherapy are uncommon in adults, and that they usually manifest 10 -15 years after treatment make them less of a concern. It is also worth mentioning that intensity modulation using a scanned pencil beam has also been applied to proton radiotherapy; dose distributions are superior to those achievable with the more commonly employed passively scattered proton beams (Weber et al, 2004), and there is also less total body neutron dose from beam-shaping devices (Miralbell et al, 2002).…”

mentioning

confidence: 99%

Proton beam therapy

et al. 2005

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Conventional radiation therapy directs photons (X-rays) and electrons at tumours with the intent of eradicating the neoplastic tissue while preserving adjacent normal tissue. Radiation-induced damage to healthy tissue and second malignancies are always a concern, however, when administering radiation. Proton beam radiotherapy, one form of charged particle therapy, allows for excellent dose distributions, with the added benefit of no exit dose. These characteristics make this form of radiotherapy an excellent choice for the treatment of tumours located next to critical structures such as the spinal cord, eyes, and brain, as well as for paediatric malignancies.

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“…Bu konuda elde edilen verilerin çoğu geriye dönük olmakla beraber lokal kontrol sonuçları modern foton uygulamaları ile karşılaştırılabilir seviyededir. [68][69][70] Geç toksisite değerlendirmesi için genelde takip süreleri kısadır. Her ne kadar proton tedavisi ile çocuklardaki dü-şük doz alan çevre normal doku volümü azaltılma-sının faydaları bilinsede erişkinler için ölçülebilen yararları tartışmalıdır.…”

Section: Kafa Tabanı Tümörleri (Kondrosarkomlar Ve Kordomalar)unclassified

Role of proton therapy in the treatment of cancer

Hiçsönmez

2013

TJ Oncol

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Spot-scanning proton radiation therapy for recurrent, residual or untreated intracranial meningiomas

Cited by 96 publications

References 56 publications

Radiotherapy Treatment of Early-Stage Prostate Cancer with IMRT and Protons: A Treatment Planning Comparison

Radiotherapy Treatment of Early-Stage Prostate Cancer with IMRT and Protons: A Treatment Planning Comparison

Proton beam therapy

Role of proton therapy in the treatment of cancer

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