Spotlight on Trans-Synaptic Degeneration in the Visual Pathway in Multiple Sclerosis
Angeliki G Filippatou,
Peter A Calabresi,
Shiv Saidha
et al.
Abstract:A putative mechanism of neurodegeneration in multiple sclerosis (MS) is trans-synaptic degeneration (TSD), whereby injury to a neuron leads to degeneration of synaptically connected neurons. The visual system is commonly involved in MS and provides an ideal model to study TSD given its well-defined structure. TSD may occur in an anterograde direction (optic neuropathy causing degeneration in the posterior visual pathway including the optic radiations and occipital gray matter) and/or retrograde direction (post… Show more
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