Spotting sporotrichosis skin infection: The first Australian paediatric case series

Schauer, A; Campbell, Anita J.; Arthur, Ian; Blyth, Christopher C; Bowen, Asha C

doi:10.1111/jpc.14639

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Australian cases are generally associated with S. schenckii s. str. and S. globosa following a sapronotic route, mainly in Queensland, New South Wales, and Western Australia [ 81 , 82 , 83 ]. In these areas, outbreaks of sporotrichosis attributed to environmental sources such as hay are not uncommon.…”

Section: Trends In the Epidemiology Of Sporothrix ...mentioning

confidence: 99%

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Rodrigues

Gonçalves

Carvalho

et al. 2022

JoF

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Sporotrichosis, a human and animal disease caused by Sporothrix species, is the most important implantation mycosis worldwide. Sporothrix taxonomy has improved in recent years, allowing important advances in diagnosis, epidemiology, and treatment. Molecular epidemiology reveals that S. brasiliensis remains highly prevalent during the cat-transmitted sporotrichosis outbreaks in South America and that the spread of S. brasiliensis occurs through founder effects. Sporothrix globosa and S. schenckii are cosmopolitan on the move, causing major sapronoses in Asia and the Americas, respectively. In this emerging scenario, one-health approaches are required to develop a creative, effective, and sustainable response to tackle the spread of sporotrichosis. In the 21st century, it has become vital to speciate Sporothrix, and PCR is the main pillar of molecular diagnosis, aiming at the detection of the pathogen DNA from clinical samples through multiplex assays, whose sensitivity reaches remarkably three copies of the target. The treatment of sporotrichosis can be challenging, especially after the emergence of resistance to azoles and polyenes. Alternative drugs arising from discoveries or repositioning have entered the radar of basic research over the last decade and point to several molecules with antifungal potential, especially the hydrazone derivatives with great in vitro and in vivo activities. There are many promising developments for the near future, and in this review, we discuss how these trends can be applied to the Sporothrix-sporotrichosis system to mitigate the advance of an emerging and re-emerging disease.

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Section: Trends In the Epidemiology Of Sporothrix ...mentioning

confidence: 99%

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Rodrigues

Gonçalves

Carvalho

et al. 2022

JoF

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“…Although uncommon in Australia, more than 200 locally acquired cases have been described across Western Australia, Queensland, New South Wales and the Northern Territory since the 1950s. These include sporadic cases and four larger outbreaks associated with mouldy hay exposure 2 …”

Section: Discussionmentioning

confidence: 99%

Violaceous skin lesions on a returned traveller

Griffin

Wong

Morrissey

et al. 2021

Medical Journal of Australia

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Violaceous skin lesions on a returned traveller Clinical recordA 34-year-old Australian man, with no relevant past medical history, presented to the emergency department with 4 weeks of progressive, nodular skin lesions on his non-dominant hand and arm (Box 1, A). He was systemically well, without constitutional symptoms, and worked as a plumber in suburban Melbourne. He was an avid gardener and had completed a 4-week permaculture course in Pisac, Peru, 8 weeks prior. While in Peru, he sustained multiple insect bites and scratches on his hands while working with soil. He had no animal bites or fresh or salt water exposure. He completed a 5-day course of cephalexin with his local doctor, without improvement, upon the emergence of the first lesion on this thumb.Examination revealed a well man, with multiple large, tender, violaceous, lesions tracking up his left arm. The lesions were raised, warm and ulcerated. Larger lesions were fluctuant, with serous discharge (Box 1, A). The remainder of his skin and physical examination was normal with no lymphadenopathy and normal vital signs. Medical educationMJA 215 (9) ▪

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Zoonotic feline sporotrichosis: a small case cluster in Perth, Western Australia, and a review of previous feline cases from Australia

Miranda,

Gillett,

Ames

et al. 2024

Aust Veterinary J

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Sporotrichosis is caused by species of the fungus Sporothrix that affect human and several animal species. The transmission of sporotrichosis is classically from an environmental source following penetrating injury. The alternative zoonotic route has gained attention due to the rapid and significant spread of cat‐transmitted sporotrichosis in South America and Malaysia, resulting in several thousand human and feline cases in recent decades, especially in Brazil. In Australia, sporotrichosis is sporadic and mainly related to environmental sources. Although feline sporotrichosis is rare in Australia, zoonotic transmission occurred in two of five reported cases, including a recent case cluster, which is reported in this article. The investigation of such cases in Australia is important, as cats not only represent a source of infection living in close proximity with humans, but also, they may represent sentinels for the environmental presence of the fungus. To encourage the investigation and reporting of new veterinary cases, we have reviewed Australian sporotrichosis cases in humans and cats and report a new case cluster of feline sporotrichosis in Perth, WA, Australia, with zoonotic transmission. The index case was a kitten who developed severe facial sporotrichosis with prominent involvement of the nasal planum. Two human cases – one suspected and one confirmed – are also described in the owner, who was a veterinary nurse, and the attending veterinarian, respectively, probably from handling the kitten while not wearing gloves. Later, another mature cat in the same household also became infected. The affected cats were successfully treated using combination of itraconazole and terbinafine. To the best of our knowledge, this is only the second case of cat‐transmitted sporotrichosis reported from Australia.

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Spotting sporotrichosis skin infection: The first Australian paediatric case series

Cited by 3 publications

References 6 publications

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Current Progress on Epidemiology, Diagnosis, and Treatment of Sporotrichosis and Their Future Trends

Violaceous skin lesions on a returned traveller

Zoonotic feline sporotrichosis: a small case cluster in Perth, Western Australia, and a review of previous feline cases from Australia

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