SPP1 rs4754 and its epistatic interactions with SPARC polymorphisms in gastric cancer susceptibility

Chen, Le Zong; He, Cai; Su, Xuan; Peng, Jun; Chen, Dong Liang; Ye, Zu‐Lu; Yang, Dong; Wang, Zi‐Xian; Wang, Zhen; Shao, Jian Yong; Xu, Rui

doi:10.1016/j.gene.2017.09.053

Cited by 20 publications

(20 citation statements)

References 27 publications

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“…Previous data have highlighted the critical role of SPP1 in GC (L. Z. Chen et al, 2018). Evidence shows that the silencing of SPP1 could, in fact, inhibit the AKT signaling pathway, and therefore prevent ovarian cancer growth in mice (Zeng, Zhou, Wu, & Xiong, 2018).…”

Section: Introductionmentioning

confidence: 99%

Retracted: Targeting of SPP1 by microRNA‐340 inhibits gastric cancer cell epithelial–mesenchymal transition through inhibition of the PI3K/AKT signaling pathway

Song

Shi

Liu

et al. 2019

Journal Cellular Physiology

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Gastric cancer (GC) is a common heterogeneous disease. The critical roles of microRNA‐340 (miR‐340) in the development and progression of GC were emphasized in accumulating studies. This study aims to examine the regulatory mechanism of miR‐340 in GC cellular processes. Initially, microarray technology was used to identify differentially expressed genes and regulatory miRs in GC. After that, the potential role of miR‐340 in GC was determined via ectopic expression, depletion, and reporter assay experiments. Expression of secreted phosphoprotein 1 (SPP1), miR‐340, phosphatidylinositol 3‐kinase/protein kinase B (PI3K/AKT) pathway, and epithelial–mesenchymal transition (EMT)‐related genes was measured. Moreover, to further explore the function of miR‐340 in vivo and in vitro, proliferation, apoptosis, migration, invasion, and tumorigenic capacity were evaluated. SPP1 was a target gene of miR‐340 which could then mediate the PI3K/AKT signaling pathway by targeting SPP1 in GC. Furthermore, miR‐340 levels were reduced and SPP1 was enriched in GC tissues and cells, with the PI3K/AKT signaling pathway being activated. Inhibitory effects of upregulated miR‐340 on SPP1 and the PI3K/AKT signaling pathway were confirmed in vivo and in vitro. Overexpression of miR‐340 or the silencing of SPP1 inhibited GC cell proliferation, invasion, migration, and EMT process, but promoted apoptosis of GC cells. Typically, targeting of SPP1 by miR‐340 may contribute to the inhibition of proliferation, migration, invasion, and EMT of GC cells via suppression of PI3K/AKT signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Retracted: Targeting of SPP1 by microRNA‐340 inhibits gastric cancer cell epithelial–mesenchymal transition through inhibition of the PI3K/AKT signaling pathway

Song

Shi

Liu

et al. 2019

Journal Cellular Physiology

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“…In multiple malignant tumors such as gastric, esophageal, and colorectal cancers, SPP1 could be detected to have a significantly high expression. Moreover, the SPP1 expression level was significantly higher in tumors with higher malignancy than that in tumors with lower malignancy (Lin et al, 2015;Xu et al, 2017;Chen et al, 2018;Assidi et al, 2019). Xu et al (2017) found that SPP1 could activate the epithelial-mesenchymal transition (EMT) pathway to promote the metastasis of colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Xu et al (2017) found that SPP1 could activate the epithelial-mesenchymal transition (EMT) pathway to promote the metastasis of colorectal cancer. Chen et al (2018) detected the potential functional marker single nucleotide polymorphism (tagSNP) of SPP1 by PCR and found that the frequency of SPP1 rs4754 genotype was significantly different from that of the control group, and the rs4754 TT genotype increased the risk of gastric cancer. Qin et al (2018) found that SPP1 was upregulated in tumor tissues and plasma of patients with head and neck cancer, and the overexpression of SPP1 or the elevated level of plasma SPP1 in head and neck cancer tissues was associated with high malignancy and poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Expression and Its Clinical Significance of the Secreted Phosphoprotein 1 in Lung Adenocarcinoma

et al. 2020

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“…rs4754 polymorphism was observed to be associated with the risk of gastric cancer and has an important effect in gastric carcinogenesis [69].…”

Section: Discussionmentioning

confidence: 99%

Identification of Novel Hub Genes Associated With Gastric Cancer Using Integrated Bioinformatics Analysis

Zhang

Qiao

et al. 2020

Preprint

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Background: Gastric cancer (GC) is one of the most common solid malignant tumors worldwide with a high-recurrence-rate. Identifying the molecular signatures and specific biomarkers of GC might provide novel clues for GC prognosis and targeted therapy.Methods: Gene expression profiles were obtained from the ArrayExpress and Gene Expression Omnibus database. Differentially expressed genes (DEGs) were picked out by R software. The hub genes were screened by cytoHubba plugin. Their prognostic values were assessed by Kaplan–Meier survival analyses and the gene expression profiling interactive analysis (GEPIA). Finally, qRT-PCR in GC tissue samples was established to validate these DEGs. Results: Total of 295 DEGs were identified between GC and their corresponding normal adjacent tissue samples in E-MTAB-1440, GSE79973, GSE19826, GSE13911, GSE27342, GSE33335 and GSE56807 datasets, including 117 up-regulated and 178 down-regulated genes. Among them, 7 vital upregulated genes (HMMR, SPP1, FN1, CCNB1, CXCL8, MAD2L1 and CCNA2) were selected. Most of them had a significantly worse prognosis except SPP1. Using qRT-PCR, we validated that their transcriptions in our GC tumor tissue were upregulated except SPP1 and FN1, which correlated with tumor relapse and predicts poorer prognosis in GC patients.Discussion: We have identified 5 upregulated DEGs (HMMR, CCNB1, CXCL8, MAD2L1, and CCNA2) in GC patients with poor prognosis using integrated bioinformatical methods, which could be potential biomarkers and therapeutic targets for GC treatment.

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SPP1 rs4754 and its epistatic interactions with SPARC polymorphisms in gastric cancer susceptibility

Cited by 20 publications

References 27 publications

Retracted: Targeting of SPP1 by microRNA‐340 inhibits gastric cancer cell epithelial–mesenchymal transition through inhibition of the PI3K/AKT signaling pathway

Retracted: Targeting of SPP1 by microRNA‐340 inhibits gastric cancer cell epithelial–mesenchymal transition through inhibition of the PI3K/AKT signaling pathway

Analysis of Expression and Its Clinical Significance of the Secreted Phosphoprotein 1 in Lung Adenocarcinoma

Identification of Novel Hub Genes Associated With Gastric Cancer Using Integrated Bioinformatics Analysis

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