2023
DOI: 10.1101/2023.05.23.541910
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Spp1 secreted by macrophages impairs osteogenic ability of Ctsk+Fmod+periosteal cells in jaw bone

Abstract: Periosteum, which covers the surface of most bones, mediates bone regeneration through endochondral ossification during fracture repair and intramembranous ossification under steady state. Periosteal cells (PCs) of jaw bones are different from those of long bones in phenotypic characteristics and functions. So far, the role of periosteum in jaw bones during bone grafting remain unclarified. Here we propose a subperiosteal bone grafting model based on the clinical procedures. By integrating single-cell RNA sequ… Show more

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