Considering the implications the formulation may have on the effectiveness and residuality of an active ingredient, four trials were conducted comparing two commercial formulations of the diazinon insecticide, two of acetamiprid, two of lambda-cyhalothrin, and, finally, three formulations of imidacloprid. For diazinon and acetamiprid, the comparison parameters used correspond to efficacy against three key pests in apple trees: Cydia pomonella, Diaspidiotus perniciosus, and Pseudococcus viburni; for l-cyhalothrin, efficacy against C. pomonella was compared; and for imidacloprid, differences in control P. viburni were established. In all cases, their persistence was established in terms of initial and final residue levels in samples of fruits, at 1 and 25 days after application (DAA). Different formulations of the same insecticide correspond to a relevant factor in the general behavior that each product presents in field conditions, being able to affect parameters such as its persistence in the fruit and/or initial deposit of the active ingredient. This variation was demonstrated in the comparison performed on acetamiprid, imidacloprid, and diazinon, but it was not so in l-cyhalothrin. Efficacy was affected in all parameters evaluated for each group of insecticides, demonstrating that different formulations can deliver different biological activity in the control of various pests.