Spray-Dried and Spray-Freeze-Dried Powder Formulations of an Anti-Interleukin-4Rα Antibody for Pulmonary Delivery

Discovery of new cocrystals beyond serendipity: lessons learned from successes and failures

“…In the context of cocrystallization, these techniques have recently emerged as promising strategies for fabricating kinetically stable and energetic cocrystals, 18,[99][100][101][102] which excel in light of their simplicity, scalability, and capability to achieve precise control over particle attributes for inhaled drug delivery purposes. [103][104][105][106] Remarkably, Alhalaweh et al serendipitously discovered a 1 : 1 urea-succinic acid cocrystal using spray drying in either water or 2-propanol, where the cocrystal formation was kinetically mediated by the amorphous state of the materials. 107,108 The urea-succinic acid cocrystal exhibits stoichiometric diversity that could exist in both 1 : 1 and 2 : 1 molar ratios.…”

Inhalable neutralizing antibodies – promising approach to combating respiratory viral infections

“…The portable DPIs can be easily distributed to large population of outpatients during an outbreak for prophylaxis or treatment at the early stage of infection. Several studies have already demonstrated the feasibility of formulating antibody into inhalable dry powder using various particle engineering techniques [75][76][77]. Most of the preclinical work has been focused on nebulization; therefore, more effort should be put into developing dry powder aerosols of antibodies, including nasal powders, which have not been properly investigated.…”

Neutralisation of SARS-CoV-2 by monoclonal antibody through dual targeting powder formulation

“…A dual targeting formulation which contained particles with bimodal size distribution was prepared by blending spray dried powder of WKS13 of two different particle sizes, with the large particles (> 10 μm) for nasal deposition whilst the small particles (< 5 μm) for lung deposition. Cyclodextrin was used as the major excipient as it has been demonstrated to be an effective stabiliser to preserve protein activity during spray drying [ 13 , 14 ], with leucine added to the formulation in attempt to improve powder dispersibility [ 15 ]. The physicochemical properties and aerosol performance of the dual targeting formulation were examined.…”