Spray‐Dried Particle Morphologies

Abstract

Particulate powders and particle morphologies produced by spray drying are discussed, along with factors that afJect powder quality, e.g. process conditions, and particle properties. Structural categories of spray-dried particles are demonstrated and related to various drying mechanisms. The methodr of studying particle morphology are also outlined with particular reference to the single droplet drying method, reportedly analogous to industrial spray drying and possibly other particulate formation processes. The advantages and disadvantages of the method are discussed and the importance of particle morphology to powder technology emphasised.Particulate powders, as opposed to powders produced by crushing or grinding of a solid after drying or processing, are beneficial to both the manufacturer and the consumer alike. From the manufacturers point of view, particulate powders can be produced continuously, have high throughputs, large surface areas and therefore high drying rates. They are convenient to transport and package both on and off the manufacturing site, and are ready to use without further preparation. They can also be moulded and machined (usually with the incorporation of a binder) into any shape or form. But most importantly, the specifications of a particulate powder can be rapidly altered at the manufacturing stage to suit customer taste, fashion or market demand.

Comparison of a Novel Miniaturized Screening Device with Büchi B290 Mini Spray-Dryer for the Development of Spray-Dried Solid Dispersions (SDSDs)

“…The proposed miniaturized equipment was qualified by producing binary SDSDs of itraconazole at the milligram scale and comparing the powder/particle properties with respective samples produced by the laboratory dryer. Characterization of the structural shape of spray-dried particles is of particular interest as it provides evidence on how solvent evaporation and particles' formation occur during the drying process [39]. Since SDSD is a formulation intermediate that needs to be further processed prior to preclinical or clinical application, powder properties such as bulk density and flowability are critical quality attributes.…”

Preparation and Properties of Olive Oil Microcapsules

“…Spray drying is a commercial process which is widely used in large-scale production of encapsulated flavors and volatile. The merits of process have ensured its dominance; these include availability of equipment, low process cost, wide choice of carrier solids, good retention of volatiles, good stability of finished product, and large-scale production in continuous mode [4]. In recent years, the technology of microcapsules has played an important role in preparing functional textile [5].…”