Spray-dried tenofovir alafenamide-chitosan nanoparticles loaded oleogels as a long-acting injectable depot system of anti-HIV drug

Narayanan, Vedha Hari B; Lewandowski, Artur; Durai, Ramya Devi; Gonciarz, Weronika; Wawrzyniak, P.; Brzeziński, Marek

doi:10.1016/j.ijbiomac.2022.09.164

Cited by 26 publications

(16 citation statements)

References 70 publications

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“…This is a clear indication of the drug amorphization of TDF in the chitosan polymer matrix. The characteristics peaks of TDF were reported in the same region earlier by Zaman et al justifying our findings. , Therefore, the disappearance of sharp crystalline TDF peaks and the presence of broad and broad peaks as observed in the diffractogram of formulation ECH-4, confirmed that drug (TDF) had undergone solid-state transition during the emulsification process in the presence of chitosan. , This can be interpreted as a clear indication of the drug’s molecular dispersion within the chitosan matrix as a solid–solid solution.…”

Section: Resultsmentioning

confidence: 99%

“…73,45 Therefore, the disappearance of sharp crystalline TDF peaks and the presence of broad and broad peaks as observed in the diffractogram of formulation ECH-4, confirmed that drug (TDF) had undergone solid-state transition during the emulsification process in the presence of chitosan. 77,78 This can be interpreted as a clear indication of the drug's molecular dispersion within the chitosan matrix as a solid−solid solution.…”

Section: Ftir Analysismentioning

confidence: 99%

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Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Avlani,

Kumar,

H.N

2023

Mol. Pharmaceutics

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Tenofovir disoproxil fumarate (TDF)-loaded bioadhesive chitosan microparticles (CM) were developed by an emulsification internal gelation technique. Among different batches produced, ECH-4 was found to display a high % entrapment efficiency (68.93 ± 1.76%) and sustained drug release of 88.05 ± 0.38% at 24 h. Solid state characterization of ECH-4 employing DSC and PXRD indicated that the TDF existed in an amorphous state as a solid−solid solution in chitosan. Scanning electron microscopy revealed CM of ECH-4 was spherical in shape with a rough surface topography. Laser scattering analysis using Malvern Master sizer indicated that particle size of ECH-4 was in the range of 0.52 ± 0.10 μm to 284.79 ± 21.42 μm with a surface-mean diameter of 12.41 ± 0.06 μm. Ex vivo mucoadhesion studies using rabbit mucosa as a substrate indicated that 10.34 ± 2.08% of CM of ECH-4 was retained at the end of 24 h. The microparticles of ECH-4 were incorporated into dispersible tablets (DT-TCM) intended for intravaginal administration, in view to arrest the preexposure transmission of HIV during sexual intercourse. In vitro release from the dispersible tablet (F3) into simulated vaginal fluid (pH 4.5) displayed a sustained release profile of TDF as 89.98 ± 1.61% of TDF was released at 24 h. The in vitro dissolution profile of the DT-TCM was found to be similar to that of TDF loaded CM with the values of f 1 (difference factor) and f 2 (similarity factor) being 1.52 and 78.02, respectively. Therefore, DT-TCM would be a promising novel drug delivery platform for pre-exposure prophylaxis against HIV.

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Section: Resultsmentioning

confidence: 99%

Section: Ftir Analysismentioning

confidence: 99%

Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Avlani,

Kumar,

H.N

2023

Mol. Pharmaceutics

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“…These networks, created from both synthetic and natural polymers, are designed for specific drug delivery applications. Chitosan-based gels [ 5 , 46 , 47 , 64 ] are particularly noted for their biocompatibility and gel formation through ionic crosslinking. Similarly, poly(lactic-co-glycolic acid) (PLGA)-based gels [ 7 , 13 , 40 , 42 , 43 , 60 ] are valued for their biodegradability and capacity for sustained drug release.…”

Section: Long-acting Gel Compositionsmentioning

confidence: 99%

Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas

Omidian,

Wilson

2024

Pharmaceuticals

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This multifaceted landscape of long-acting gels in diverse medical fields, aims to enhance therapeutic outcomes through localized treatment and controlled drug release. The objective involves advancements spanning cancer treatment, immunotherapy, diabetes management, neuroendocrine disorders, ophthalmic applications, contraception, HIV/AIDS treatment, chronic diseases, wound care, and antimicrobial treatments. It explores the potential of long-acting gels to offer sustained and extended drug release, targeted therapy, and innovative administration routes while addressing limitations such as scalability challenges and regulatory hurdles. Future directions focus on personalized therapies, biodegradability, combination therapies, interdisciplinary innovation, regulatory considerations, and patient-centric development. This comprehensive review highlights the pivotal role of long-acting gels in transforming therapeutic approaches and improving patient outcomes across various medical conditions.

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“…In addition, oleogels have been shown to exhibit prolonged drug release (56%) over 16 days, resulting in a 10-fold reduction in drug permeability. Overall, it has been reported that the developed Tenofovir alafenamide-chitosan polymeric nanoparticles loaded with ethylcellulose oleogels could potentially be used as an effective injectable system for the treatment of patients infected with HIV/AIDS [87]. The long-acting injectability (LAI) of oleogels loaded with Tenofovir alafenamidechitosan polymeric nanoparticles developed with ethyl cellulose and sesame oil for the prolonged release of the drug was reported for the first time by Narayanan et al It has been shown to be a unique long-acting parenteral formulation for chronic anti-retroviral therapy by ex vivo and in vitro studies.…”

Section: Applications Of Antimicrobial Nanomaterialsmentioning

confidence: 99%

“…In addition, oleogels have been shown to exhibit prolonged drug release (56%) over 16 days, resulting in a 10-fold reduction in drug permeability. Overall, it has been reported that the developed Tenofovir alafenamide-chitosan polymeric nanoparticles loaded with ethylcellulose oleogels could potentially be used as an effective injectable system for the treatment of patients infected with HIV/AIDS [87]. Even though sanitizers provide immediate hygiene benefits by disinfecting objects from microorganisms, they may damage electronic devices such as computers, refrigerators, etc.…”

Section: Applications Of Antimicrobial Nanomaterialsmentioning

confidence: 99%

Antimicrobial Nanomaterials: A Review

Yılmaz

Göktürk

Ovezova

et al. 2023

Hygiene

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Microbial colonization on various surfaces is a serious problem. Biofilms from these microbes pose serious health and economic threats. In addition, the recent global pandemic has also attracted great interest in the latest techniques and technology for antimicrobial surface coatings. Incorporating antimicrobial nanocompounds into materials to prevent microbial adhesion or kill microorganisms has become an increasingly challenging strategy. Recently, many studies have been conducted on the preparation of nanomaterials with antimicrobial properties against diseases caused by pathogens. Despite tremendous efforts to produce antibacterial materials, there is little systematic research on antimicrobial coatings. In this article, we set out to provide a comprehensive overview of nanomaterials-based antimicrobial coatings that can be used to stop the spread of contamination to surfaces. Typically, surfaces can be simple deposits of nanomaterials, embedded nanomaterials, as well as nanotubes, nanowires, nanocolumns, nanofibers, nanoneedles, and bio-inspired structures.

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Spray-dried tenofovir alafenamide-chitosan nanoparticles loaded oleogels as a long-acting injectable depot system of anti-HIV drug

Cited by 26 publications

References 70 publications

Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Development of Dispersible Vaginal Tablets of Tenofovir Loaded Mucoadhesive Chitosan Microparticles for Anti-HIV Pre-Exposure Prophylaxis

Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas

Antimicrobial Nanomaterials: A Review

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