Spray Drying as a Fast and Simple Technique for the Preparation of Extended Release Dipyridamole (DYP) Microparticles in a Fixed Dose Combination (FDC) Product with Aspirin

Hamishehkar, Hamed; Valizadeh, Hadi; Alasty, P.; Monajjemzadeh, Farnaz

doi:10.1055/s-0033-1354364

Cited by 5 publications

(4 citation statements)

References 6 publications

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“…Particle size and distribution, shape, and crystallinity of powders also control the flow properties of powders [8]. Solid dispersions have been applied to obtain a homogeneous distribution of the drug in a solid state to disperse a liquid or waxy compounds into a solid dosage form [9,10]. Our literature review shows no attempt on improving the DVX flowability to introduce a successful tableting and capsule filling procedures for pharmaceutical industries.…”

Section: Conclusion Findings Suggest That the Spray Drying Techniquementioning

confidence: 99%

Application of Spray Drying Technique for Flowability enhancement of Divalproex Sodium

et al. 2017

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Section: Conclusion Findings Suggest That the Spray Drying Techniquementioning

confidence: 99%

Application of Spray Drying Technique for Flowability enhancement of Divalproex Sodium

et al. 2017

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“…FTIR is a method capable of revealing the drug physicochemical properties inside the intact microparticles 26,27 . As mentioned earlier, the drug precursor was a water soluble salt at the beginning of the manufacturing process.…”

Section: Ftir Analysismentioning

confidence: 99%

Physicochemical and in vitro mucoadhesive properties of microparticles/discs of betamethasone for the management of oral lichen planus

Monajjemzadeh

Gholizadeh

Mobaraki

et al. 2015

Pharmaceutical Development and Technology

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This study involved the preparation and evaluation of buccal-mucoadhesive microparticles/discs of bethamethasone disodium phosphate (BDSP). The microparticles were prepared using the emulsion solvent diffusion method. Microparticles were prepared and characterized by encapsulation efficiency particle size, Fourier Transform Infra Red (FTIR) spectrums, Differential Scanning Calorimetric (DSC) thermograms and mucoadhesive properties. FTIR studies reported that BDSP was changed to bethamethasone base molecule inside the intact microparticles. The best drug to polymers ratio in microparticles was F containing 50 mg drug, 50 mg HPMC (as non-ionic and hydrophilic polymer) and 50 mg carbomer 934p (an anionic mucoadhesive polymer). The production yield of F1 microparticles was calculated as 78.60% with loading efficiency of about 65.14% and the mean particle size was also measured as 281.84 μm. It was proposed that during the microparticle preparation procedure, water soluble salt of the drug may be converted to the base which could be more effective in the buccal mucosa due to its higher partition coefficient and lipophilicity. The highest and lowest releases resulted from the discs prepared from F and F, respectively, compared with the commercial tablet and untreated drug powder (p < 0.05). The data revealed that the discs exhibited good percentage of mucoadhesion (F, 326 g/cm). It may be concluded that drug loaded buccal-mucoadhesive microparticles are a suitable delivery system for BDSP, and may be used in the effective management of lichen planus.

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“…Pharmaceutical formulators attempt to reach the most stable formulations, which are costeffective and can gain customer acceptance. [1][2][3] Kojic acid (Ka) is a metabolite derived from the activity of various species of Aspergillus and Penicillium fungi. KA was first used in Japan as a skin lightening agent in 1988.…”

Section: -Introductionmentioning

confidence: 99%

“…Pharmaceutical formulators attempt to reach the most stable formulations, which are cost-effective and can gain customer acceptance. 1 - 3 …”

Section: Introductionmentioning

confidence: 99%

Comparative Stability of Two Anti-Hyperpigmentation Agents: Kojic Acid as a Natural Metabolite and Its Di-Palmitate Ester, Under Oxidative Stress; Application to Pharmaceutical Formulation Design

et al. 2021

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Purpose: Kojic acid a natural metabolite (KA) and its dipalmitate ester, kojic acid dipalmitate (Kadp) are both prescribed to treat skin hyperpigmentation. Stress test reveals the intrinsic stability of active ingredients and leads to selection of the suitable formulations. This research evaluates the comparative stability of KA and its di-palmitate ester under liquid oxidative stress. Methods: The HPLC-UV/PDA method with a C18 column was utilized. Liquid oxidative stress was induced using hydrogen peroxide (H2O2). Degradation was separately induced for each drug, and they were compared to each other. Results: Kadp degraded more rapidly in similar liquid oxidative stress conditions than KA did. The superior degradation model was the first order for both drugs based on the MPE values, indicating the dependency of the reaction rate on the initial concentration of the reactive substance. Ring opening was proposed as the most possible theory for KA and Kadp oxidative degradation. Conclusion: It is suggested to use KA instead of Kadp in less stable formulations, such as extemporaneous preparations. The incorporation of antioxidant excipients in Kadp formulations is recommended for yielding better stability results. Formulating Kadp in the internal phase of o/w emulsion formulations may protect this susceptive molecule from oxidative degradation during the shelf life of the pharmaceutical preparation. Further studies are required to study the exact mechanism of the degradation process.

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Spray Drying as a Fast and Simple Technique for the Preparation of Extended Release Dipyridamole (DYP) Microparticles in a Fixed Dose Combination (FDC) Product with Aspirin

Abstract: Findings proposed a new formulation (F7) as an alternative to innovative brand and proved spray drying as a practice compatible with pharmaceutical industries and as a successful method for sustaining the DYP release rate from prepared microparticles in a FDC dosage form.

Cited by 5 publications

References 6 publications

Application of Spray Drying Technique for Flowability enhancement of Divalproex Sodium

Application of Spray Drying Technique for Flowability enhancement of Divalproex Sodium

Physicochemical and in vitro mucoadhesive properties of microparticles/discs of betamethasone for the management of oral lichen planus

Comparative Stability of Two Anti-Hyperpigmentation Agents: Kojic Acid as a Natural Metabolite and Its Di-Palmitate Ester, Under Oxidative Stress; Application to Pharmaceutical Formulation Design

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