Spray flash evaporation SFE process: Identification of the driving parameters on evaporation to tune particle size and morphology

Lobry, Emeline; Berthe, Jean‐Edouard; Spitzer, Denis

doi:10.1016/j.ces.2020.116307

Cited by 6 publications

(6 citation statements)

References 39 publications

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“…The solution, which was composed of melamine (0.3 g) and nitroglycerin (0.5 g) dissolved in a mixture of ethanol (500 mL) and water (100 mL), was sprayed through a 100 μm nozzle kept at 100 °C, by applying an upstream pressure of 40 bar, in an atomization chamber maintained under dynamic vacuum (5 mbar). The temperature of the sprayed solution was set to obtain the highest possible pressure ratio between saturation pressure and chamber pressure [ 22 ], while minimizing nitroglycerin evaporation. The slight natural acidity of the melamine solution (pH = 5) and the very short heating time of the solution (a few seconds) do not allow the hydrolysis of nitroglycerin, which was observed by Halasz et al in an aqueous alkaline medium (pH = 9–12) under the action of prolonged heating [ 23 ].…”

Section: Methodsmentioning

confidence: 99%

Nitroglycerin trapping in melamine matrices

Schwartz,

Comet,

Lallemand

et al. 2023

Heliyon

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Section: Methodsmentioning

confidence: 99%

Nitroglycerin trapping in melamine matrices

Schwartz,

Comet,

Lallemand

et al. 2023

Heliyon

Self Cite

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“…Spray Flash Evaporation (SFE) is a technique based on the injection of a solution into an ambient gas at low pressure, and it is used, for example, in the pharmaceutical, food and chemical industries, for for the crystallization of submicron-sized particles 15 . In these applications, various species are used as solvents, including methyl acetate, ethyl acetate, acetone, and methanol.…”

Section: Applicationsmentioning

confidence: 99%

A model of droplet evaporation: New mathematical developments

et al. 2022

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A previously developed model for mono-component droplet evaporation is revisited using new mathematical tools for its analysis. The analysis is based on steady-state mass, momentum and energy balance equations for the vapour and air mixture surrounding a droplet. The previously obtained solution to these equations was based on the assumption that the parameter ε (proportional to the squared ratio of the diffusion coefficient and droplet radius) is equal to zero. The analysis presented in the paper is based on the method of integral manifolds and it allowed us to present the droplet evaporation rate as the sum of the evaporation rate predicted by the model based on the assumption that ε = 0 and the correction proportional to ε. The correction is shown to be particularly important in the case of small water andmethanol droplets (diameters less than 5 μm) evaporating in air at low pressure (0.1 atm.). In this case, this correction could reach 35% of the original evaporation rate. In the case of evaporation of relatively large droplets (with radii more than 10 μm) in air at atmospheric and higher pressures these corrections are shown to be small (less than 10−3 of the evaporation rate predicted by the model based on the assumption that ε = 0).

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“…27 28 30 31 32 Currently, multiple theoretical formulas can be used to predict droplet size changes under different parameter conditions. 20 33 34 Theoretical droplet size d d can be calculated through Equation (1) 21 :…”

Section: Introductionmentioning

confidence: 99%

A Technical Feasibility of Aqueous Aerosol Generation Based on the Flashing Jet: Effects of Overheat Degree, Jetting Rate, Jetting Volume, and Liquid Type

Zheng,

Yuan,

Wang

2023

Pharmaceutical Fronts

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A previously established flashing jet inhaler prototype (FJ prototype) can produce an aqueous aerosol but cannot steadily provide inhalable aerosol (2–5 μm). This study aims to optimize the atomization performance of the FJ prototype and generate inhalable aqueous aerosols. The effects of overheat degree, jetting rate, jetting volume, and liquid type on atomization performance were assessed by determining output aerosol's mass median aerodynamic diameter (MMAD) and aerodynamic particle size distribution. Drug distribution of active ingredients in different liquid types was also measured. A Pari nebulizer was used as a reference device. Our data suggested that MMAD is negatively correlated with the overheat degree and jetting rate, but has no significant relationship with the jetting volume. The effect of jetting rate is weaker than that of the overheat degree. When normal saline was used as the atomization liquid, output aerosol's MMAD at the FJ prototype and Pari nebulizer were 1.98 ± 0.18 and 2.50 ± 0.81 μm, respectively. The addition of a surfactant significantly decreases MMAD both in solution and in suspension, but the suspended particles had no effect on the residual level and atomization performance of the FJ prototype. When ventolin was used as the atomization liquid, the MMAD of the FJ prototype and Pari nebulizer was 2.1 ± 0.2 and 1.7 ± 0.2 μm, respectively, while the fine particle dosage (FPD) in percent of the nominal dose (%ND) was 50.4 ± 3.1 and 53.1 ± 7.2%, respectively. When pulmicort respules was used as the atomization liquid, the MMAD of the FJ prototype and Pari nebulizer was 2.5 ± 0.5 and 4.6 ± 0.2 μm respectively, while the FPD (%ND) was 30.1 ± 5.6 and 58.6 ± 5.1%, respectively. The FJ prototype not only delivers inhalable aqueous aerosol but also has a potential advantage in the atomization of suspension or poorly soluble drugs.

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Spray flash evaporation SFE process: Identification of the driving parameters on evaporation to tune particle size and morphology

Cited by 6 publications

References 39 publications

Nitroglycerin trapping in melamine matrices

Nitroglycerin trapping in melamine matrices

A model of droplet evaporation: New mathematical developments

A Technical Feasibility of Aqueous Aerosol Generation Based on the Flashing Jet: Effects of Overheat Degree, Jetting Rate, Jetting Volume, and Liquid Type

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