Spray-freeze-dried liposomal ciprofloxacin powder for inhaled aerosol drug delivery

Sweeney, Lyle G.; Wang, Zhaolin; Löebenberg, Raimar; Wong, Jonathan P.; Lange, Carlos F.; Finlay, Warren H.

doi:10.1016/j.ijpharm.2005.09.010

Cited by 104 publications

(42 citation statements)

References 21 publications

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“…Accordingly, the development of stable liposomes is a prerequisite for their exploitation in the delivery of therapeutic drugs [10,11] . For many years, attempts have been made to improve the stability of liposomes by several methods, including preparing more stable bilayers [12] , coating their surface with protecting polymers [13][14][15][16] , and modifying charge [17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Proliposomes for oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo

Chu

Tong

et al. 2011

Acta Pharmacol Sin

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Aim: To formulate proliposomes with a polyphase dispersed system composed of soybean phospholipids, cholesterol, isopropyl myristate and sodium cholate to improve the oral bioavailability of dehydrosilymarin, an oxidized form of herbal drug silymarin. Methods: Dehydrosilymarin was synthesized from air oxidation of silymarin in the presence of pyridine, and proliposomes were prepared by a film dispersion-freeze drying method. Morphological characterization of proliposomes was observed using a transmission electron microscope. Particle size and encapsulation efficiency of proliposomes were measured. The in vitro release of dehydrosilymarin from suspension and proliposomes was evaluated. The oral bioavailability of dehydrosilymarin suspension and proliposomes was investigated in rabbits. Results: The proliposomes prepared under the optimum conditions were spherical and smooth with a mean particle size in the range of 7 to 50 nm. Encapsulation efficiency was 81.59%±0.24%. The in vitro accumulative release percent of dehydrosilymarinloaded proliposomes was stable, which was slow in pH 1.2, and increased continuously in pH 6.8, and finally reached 86.41% at 12 h. After oral administration in rabbits, the relative bioavailability of proliposomes versus suspension in rabbits was 228.85%. Conclusion: Proliposomes may be a useful vehicle for oral delivery of dehydrosilymarin, a drug poorly soluble in water.

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Section: Introductionmentioning

confidence: 99%

Proliposomes for oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo

Chu

Tong

et al. 2011

Acta Pharmacol Sin

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“…[29][30][31][32][33] To the best of our knowledge, this is the only study demonstrating the use of agglomerated nanoparticles of theophylline as a dry powder for inhalers. Therefore, the aim of this study was to formulate self-assembled, theophylline nanoparticle agglomerates as a dry powder for inhalers.…”

Section: Introductionmentioning

confidence: 99%

Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

Salem¹,

Abdelrahim²,

Eid³

et al. 2011

IJN

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Background: Nanosized dry powder inhalers provide higher stability for poorly water-soluble drugs as compared with liquid formulations. However, the respirable particles must have a diameter of 1–5 μm in order to deposit in the lungs. Controlled agglomeration of the nanoparticles increases their geometric particle size so they can deposit easily in the lungs. In the lungs, they fall apart to reform nanoparticles, thus enhancing the dissolution rate of the drugs. Theophylline is a bronchodilator with poor solubility in water. Methods: Nanosized theophylline colloids were formed using an amphiphilic surfactant and destabilized using dilute sodium chloride solutions to form the agglomerates. Results: The theophylline nanoparticles thus obtained had an average particle size of 290 nm and a zeta potential of −39.5 mV, whereas the agglomerates were 2.47 μm in size with a zeta potential of −28.9 mV. The release profile was found to follow first-order kinetics (r 2 > 0.96). The aerodynamic characteristics of the agglomerated nanoparticles were determined using a cascade impactor. The behavior of the agglomerate was significantly better than unprocessed raw theophylline powder. In addition, the nanoparticles and agglomerates resulted in a significant improvement in the dissolution of theophylline. Conclusion: The results obtained lend support to the hypothesis that controlled agglomeration strategies provide an efficient approach for the delivery of poorly water-soluble drugs into the lungs.

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“…The frozen particles are collected and lyophilized, leaving behind dry particles. 14,15 Because the entire SFD process is conducted under subambient conditions, it is particularly suited for drying heat-labile materials. However, few reports about the use of SFD with nanoparticles or liposomes have been published.…”

Section: Introductionmentioning

confidence: 99%

Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor

Yin¹,

Guo²,

Gan³

et al. 2014

IJN

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In this work, an ultrasonic spray freeze-drying (USFD) technique was used to prepare a stable liposomal dry powder for transdermal delivery of recombinant human epithelial growth factor (rhEGF). Morphology, particle size, entrapment efficiency, in vitro release, and skin permeability were systematically compared between rhEGF liposomal dry powder prepared using USFD and that prepared using a conventional lyophilization process. Porous and spherical particles with high specific area were produced under USFD conditions. USFD effectively avoided formation of ice crystals, disruption of the bilayer structure, and drug leakage during the liposome drying process, and maintained the stability of the rhEGF liposomal formulation during storage. The reconstituted rhEGF liposomes prepared from USFD powder did not show significant changes in morphology, particle size, entrapment efficiency, or in vitro release characteristics compared with those of rhEGF liposomes before drying. Moreover, the rhEGF liposomal powder prepared with USFD exhibited excellent enhanced penetration in ex vivo mouse skin compared with that for powder prepared via conventional lyophilization. The results suggest that ultrasonic USFD is a promising technique for the production of stable protein-loaded liposomal dry powder for application to the skin.

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Spray-freeze-dried liposomal ciprofloxacin powder for inhaled aerosol drug delivery

Cited by 104 publications

References 21 publications

Proliposomes for oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo

Proliposomes for oral delivery of dehydrosilymarin: preparation and evaluation in vitro and in vivo

Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler

Preparation of redispersible liposomal dry powder using an ultrasonic spray freeze-drying technique for transdermal delivery of human epithelial growth factor

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